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Support: Metabolism, Toxicity and Epidemiological Studies of Fluorochemicals, with Attachments and Cover Letter dated 04/25/2000.

OTS020492910

Publication Date	2000
Page Count	6377
Abstract	Support: Single-dose Intravenous Pharmacokinetic Study of T-6246 (fc-95) in Rabbits, with Attachments & Cover Letter dated 042500. Support: Oral (stomach Tube) Developmental Toxicity Study of Pfos in Rabbits with Attachments & Cover Letter dated 0425000. Support: Fluorochemical Exposure Assessment of Decatur Chemical & Film Plant Employees, with Attachments & Cover Letter dated 042500. Support: Pfos: A Dietary Lc50 Study with the Northern Bobwhite with Cover Letter dated 042500. Support: an Acute Inhalation Toxicity Study of T-2306 Coc in the Rat with Cover Letter dated 050400. Support: Acute Oral Toxicity (ld50) Study of Fluorad Fluorochemical Surfactant Fc-95 in Rats, Cover Letter dated 050400. Support: Summary Report: 104-wk Dietary Chronic Tox & Carcinogenicity Study W/perfluorooctane Sulfonic Acid Potassium Salt (pfos: T-6295) in Rats with Cvr Ltr dated 050400. Support: 26-wk Capsule Toxicity Study W/perfluorooctane Sulfonic Acid Potassium Salt (pfos; T-6295) in Cynomolgous Monkeys with Cover Letter dated 050400. Support: Fluorochemicals in Naive Rats: Investigating the Background Serum & Liver Pfos Levels in Naive Rats fr Different Sources, with Cover Letter dated 050400. Support: Laboratory Report: Analysis of Fc's (fluorochemicals) in Samples of Children's Sera, W/attachments, dated 050400. Support: Composite Analytical Report on the Quantitative Analysis of Fluorochemicals in Environmental Samples, dated 082100. Support: Acute Oral Toxicity Screen with T-3421 (perfluorooctanesulfonamide) in Albino Rats, W/cover Sheet Referring to This & Other Studies Not Included, dated 051800. Support: Absorption & Biotransformation of N-ethyl Fose & Tissue Distribution & Elimination of C-14 after Administration of N-ethyl Fose-14c in Feed, W/cover Letter dated 050400. Support: Oral (gavage) Developmental Toxicity Study of N-etfose (trade Name: Fc-10 Fluorad) in Rats, with Cover Letter dated 050400. Support: Oral (stomach Tube) Developmental Toxicity Study of N-etfose (trade Name: Fc-10 Fluorad) in Rabbits, W/attachments & Cover Letter dated 050400. Support: 28-day Repeated Dose Oral Toxicity Study of Sample D-1 (2-(n-ethyl-n-perfluoroalkyl(c=1-8)sulfonylamino)ethyl Acrylate) in the Rat, Translated fr Japanese, Cvr Ltr 050400. Support: Technical Report Summary: Evaluation of the Bioconcentration Potential of Fm-3422, with Attachment, & Cover Letter dated 050400. Support: Bioaccumulation of Fluorochemicals in Tennessee River Fish, with Attachments, Cover Letter dated 050400. Support: Distribution Coefficient of Fm-3925 (n-methylperfluorooctane Sulfonamidoethanol) in N-octanol/water, Cover Letter dated 050400. Support: Determination of Physico-chemical Properties of Sample D-1 [2-(n-ethylperfluorooctanesulfonamido) Ethyl Acrylate], with Attachments & dated 050400. Support: Protocol & Report of Data for Exploratory 28-day Oral Toxicity Study in Rats: Telomer Alcohol, Telomer Acrylate, [ ], Pfhs, Pfos, W/ Attachments, Cvr Ltr dated 050400. Support: Letter from 3m Medical Dept to USEPA re A Draft Statistical Report on A 2-yr Rat Feeding Study of N-ethyl Perfluorooctane Sulfonamido Ethanol, dated 120400.
Keywords	Toxicology Health effects Toxic substances Potassium perfluorooctanesulfonate Laboratory animals Pharmaco kinetics Mammals Rats Rabbits Dermal Reproduction/fertility effects Teratogenicity Gavage Epidemiology CAS No. 2795-39-3 CAS No. 1763-23-1 CAS No. 335-67-1 CAS No. 55910-10-6 CAS No. 355-46-4 CAS No. 754-91-6 CAS No. 3825-26-1 CAS No. 1691-99-2 CAS No. 423-82-5 CAS No. 24448-09-7
Source Agency	Office of Toxic Substances
Corporate Authors	Hazleton Labs. America, Inc., Madison, WI.; Environmental Protection Agency, Washington, DC. Office of Toxic
Supplemental Notes	The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Document Type	Technical Report
NTIS Issue Number	200903

Support: Metabolism, Toxicity and Epidemiological Studies of Fluorochemicals, with Attachments and Cover Letter dated 04/25/2000.

Support: Metabolism, Toxicity and Epidemiological Studies of Fluorochemicals, with Attachments and Cover Letter dated 04/25/2000.
OTS020492910

Publication Date	2000
Page Count	6377
Abstract	Support: Single-dose Intravenous Pharmacokinetic Study of T-6246 (fc-95) in Rabbits, with Attachments & Cover Letter dated 042500. Support: Oral (stomach Tube) Developmental Toxicity Study of Pfos in Rabbits with Attachments & Cover Letter dated 0425000. Support: Fluorochemical Exposure Assessment of Decatur Chemical & Film Plant Employees, with Attachments & Cover Letter dated 042500. Support: Pfos: A Dietary Lc50 Study with the Northern Bobwhite with Cover Letter dated 042500. Support: an Acute Inhalation Toxicity Study of T-2306 Coc in the Rat with Cover Letter dated 050400. Support: Acute Oral Toxicity (ld50) Study of Fluorad Fluorochemical Surfactant Fc-95 in Rats, Cover Letter dated 050400. Support: Summary Report: 104-wk Dietary Chronic Tox & Carcinogenicity Study W/perfluorooctane Sulfonic Acid Potassium Salt (pfos: T-6295) in Rats with Cvr Ltr dated 050400. Support: 26-wk Capsule Toxicity Study W/perfluorooctane Sulfonic Acid Potassium Salt (pfos; T-6295) in Cynomolgous Monkeys with Cover Letter dated 050400. Support: Fluorochemicals in Naive Rats: Investigating the Background Serum & Liver Pfos Levels in Naive Rats fr Different Sources, with Cover Letter dated 050400. Support: Laboratory Report: Analysis of Fc's (fluorochemicals) in Samples of Children's Sera, W/attachments, dated 050400. Support: Composite Analytical Report on the Quantitative Analysis of Fluorochemicals in Environmental Samples, dated 082100. Support: Acute Oral Toxicity Screen with T-3421 (perfluorooctanesulfonamide) in Albino Rats, W/cover Sheet Referring to This & Other Studies Not Included, dated 051800. Support: Absorption & Biotransformation of N-ethyl Fose & Tissue Distribution & Elimination of C-14 after Administration of N-ethyl Fose-14c in Feed, W/cover Letter dated 050400. Support: Oral (gavage) Developmental Toxicity Study of N-etfose (trade Name: Fc-10 Fluorad) in Rats, with Cover Letter dated 050400. Support: Oral (stomach Tube) Developmental Toxicity Study of N-etfose (trade Name: Fc-10 Fluorad) in Rabbits, W/attachments & Cover Letter dated 050400. Support: 28-day Repeated Dose Oral Toxicity Study of Sample D-1 (2-(n-ethyl-n-perfluoroalkyl(c=1-8)sulfonylamino)ethyl Acrylate) in the Rat, Translated fr Japanese, Cvr Ltr 050400. Support: Technical Report Summary: Evaluation of the Bioconcentration Potential of Fm-3422, with Attachment, & Cover Letter dated 050400. Support: Bioaccumulation of Fluorochemicals in Tennessee River Fish, with Attachments, Cover Letter dated 050400. Support: Distribution Coefficient of Fm-3925 (n-methylperfluorooctane Sulfonamidoethanol) in N-octanol/water, Cover Letter dated 050400. Support: Determination of Physico-chemical Properties of Sample D-1 [2-(n-ethylperfluorooctanesulfonamido) Ethyl Acrylate], with Attachments & dated 050400. Support: Protocol & Report of Data for Exploratory 28-day Oral Toxicity Study in Rats: Telomer Alcohol, Telomer Acrylate, [ ], Pfhs, Pfos, W/ Attachments, Cvr Ltr dated 050400. Support: Letter from 3m Medical Dept to USEPA re A Draft Statistical Report on A 2-yr Rat Feeding Study of N-ethyl Perfluorooctane Sulfonamido Ethanol, dated 120400.
Keywords	Toxicology Health effects Toxic substances Potassium perfluorooctanesulfonate Laboratory animals Pharmaco kinetics Mammals Rats Rabbits Dermal Reproduction/fertility effects Teratogenicity Gavage Epidemiology CAS No. 2795-39-3 CAS No. 1763-23-1 CAS No. 335-67-1 CAS No. 55910-10-6 CAS No. 355-46-4 CAS No. 754-91-6 CAS No. 3825-26-1 CAS No. 1691-99-2 CAS No. 423-82-5 CAS No. 24448-09-7
Source Agency	Office of Toxic Substances
Corporate Authors	Hazleton Labs. America, Inc., Madison, WI.; Environmental Protection Agency, Washington, DC. Office of Toxic
Supplemental Notes	The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Document Type	Technical Report
NTIS Issue Number	200903