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Acute Toxicity Studies in Rabbits and Rats with Hexabromocyclododecane with Attachments.

OTS0200051

Publication Date	1978
Page Count	91
Abstract	Hexabromocyclododecane was assessed for primary eye irritation with New Zealand White rabbits (3/sex) administered 100 mg of test material in the conjunctival sac of the right eye. Treated unwashed eyes were examined at 24, 48, and 72 hours, and at 7 days. Eye irritation scores derived by the Draize method were indicative of no irritation. A primary skin irritation study was conducted with similar groups of rabbits exposed to 500 mg of test material applied to the back of each rabbit and occluded for 4 hours. Test sites were then washed and examined for irritation at 4, 24, 48, and 72 hours. No evidence was seen of primary skin irritation (mean score = 0.1). Acute dermal toxicity was assayed with rabbits (2/sex) administered doses of 20,000 mg/kg to abraded and intact dorsal skin. Test sites were occluded for 24 hours, then uncovered and washed with tap water. Observation for 14 days revealed no mortalities, but body weight gain was decreased and diarrhea was noted in 1 treated rabbit/sex. Charles River CD strain rats (5/sex) were administered oral doses of 10,000 mg/kg of test material suspended in corn oil by gavage (volume = 20 ml/kg bw) and observed for 14 days. No deaths occurred. Corneal opacity and ptosis were seen in males; diarrhea and hypoactivity were noted in females. Charles River CD rats (3/sex) were exposed to 202.14 mg/L of the test material as dust over a 4 hour exposure period. Slight dyspnea was noted during the exposure period, but no other adverse effects were seen. USEPA Status Report: Hexabromocyclododecane with Attachments.
Keywords	Toxicology Health effects Hexabromocyclododecane Primary eye irritation Mammals Rabbits Dermal Primary dermal irritation Acute toxicity Rats Oral Gavage Inhalation CAS No. 77-47-4
Source Agency	Office of Toxic Substances
Corporate Authors	Velsicol Chemical Corp., Chicago, IL.; International Research and Development Corp., Mattawan, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic
Supplemental Notes	The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Document Type	Technical Report
NTIS Issue Number	200903

Acute Toxicity Studies in Rabbits and Rats with Hexabromocyclododecane with Attachments.

Acute Toxicity Studies in Rabbits and Rats with Hexabromocyclododecane with Attachments.
OTS0200051

Publication Date	1978
Page Count	91
Abstract	Hexabromocyclododecane was assessed for primary eye irritation with New Zealand White rabbits (3/sex) administered 100 mg of test material in the conjunctival sac of the right eye. Treated unwashed eyes were examined at 24, 48, and 72 hours, and at 7 days. Eye irritation scores derived by the Draize method were indicative of no irritation. A primary skin irritation study was conducted with similar groups of rabbits exposed to 500 mg of test material applied to the back of each rabbit and occluded for 4 hours. Test sites were then washed and examined for irritation at 4, 24, 48, and 72 hours. No evidence was seen of primary skin irritation (mean score = 0.1). Acute dermal toxicity was assayed with rabbits (2/sex) administered doses of 20,000 mg/kg to abraded and intact dorsal skin. Test sites were occluded for 24 hours, then uncovered and washed with tap water. Observation for 14 days revealed no mortalities, but body weight gain was decreased and diarrhea was noted in 1 treated rabbit/sex. Charles River CD strain rats (5/sex) were administered oral doses of 10,000 mg/kg of test material suspended in corn oil by gavage (volume = 20 ml/kg bw) and observed for 14 days. No deaths occurred. Corneal opacity and ptosis were seen in males; diarrhea and hypoactivity were noted in females. Charles River CD rats (3/sex) were exposed to 202.14 mg/L of the test material as dust over a 4 hour exposure period. Slight dyspnea was noted during the exposure period, but no other adverse effects were seen. USEPA Status Report: Hexabromocyclododecane with Attachments.
Keywords	Toxicology Health effects Hexabromocyclododecane Primary eye irritation Mammals Rabbits Dermal Primary dermal irritation Acute toxicity Rats Oral Gavage Inhalation CAS No. 77-47-4
Source Agency	Office of Toxic Substances
Corporate Authors	Velsicol Chemical Corp., Chicago, IL.; International Research and Development Corp., Mattawan, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic
Supplemental Notes	The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Document Type	Technical Report
NTIS Issue Number	200903