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Inhalation Developmental Toxicology Studies: Teratology Study of Methyl Ethyl Ketone in Mice: Final Report.

DE89009563

Publication Date	1989
Personal Author	Mast, T. J.; Dill, J. A.; Evanoff, J. J.; Rommereim, R. L.; Weigel, R. J.
Page Count	245
Abstract	Methyl ethyl ketone (MEK) is a widely used industrial solvent which results in considerable human exposure. In order to assess the potential for MEK to cause developmental toxicity in rodents, four groups of Swiss (CD-1) mice were exposed to 0, 400, 1000 or 3000 ppM MEK vapors, 7 h/day, 7 dy/wk. Ten virgin females and approx.30 plug-positive females per group were exposed concurrently for 10 consecutive days (6--15 dg for mated mice). Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice on 18 dg. Uterine implants were enumerated and their status recorded. Live fetuses were sexed and examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. Exposure of pregnant mice to these concentrations of MEK did not result in apparent maternal toxicity, although there was a slight, treatment-correlated increase in liver to body weight ratios which was significant for the 3000-ppM group. Mild developmental toxicity was evident at 3000-ppM as a reduction in mean fetal body weight. This reduction was statistically significant for the males only, although the relative decrease in mean fetal body weight was the same for both sexes. 17 refs., 4 figs., 10 tabs. (ERA citation 14:025565)
Keywords	Mice Inhalation Prenatal Exposure Teratogenesis Toxicity Ketones Comparative Evaluations Dose-Response Relationships Life Span Litter Size Malformations Mortality Progress Report Sex Dependence Time Dependence Methyl ethyl ketone ERDA/560300 Concentration(Composition)
Source Agency	Technical Information Center Oak Ridge Tennessee
NTIS Subject Category	57Y - Toxicology 68G - Environmental Health & Safety 57E - Clinical Medicine
Corporate Authors	Battelle Pacific Northwest Labs., Richland, WA.; Department of Energy, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	198916
Contract Number	AC06-76RL01830

Inhalation Developmental Toxicology Studies: Teratology Study of Methyl Ethyl Ketone in Mice: Final Report.

Inhalation Developmental Toxicology Studies: Teratology Study of Methyl Ethyl Ketone in Mice: Final Report.
DE89009563

Publication Date	1989
Personal Author	Mast, T. J.; Dill, J. A.; Evanoff, J. J.; Rommereim, R. L.; Weigel, R. J.
Page Count	245
Abstract	Methyl ethyl ketone (MEK) is a widely used industrial solvent which results in considerable human exposure. In order to assess the potential for MEK to cause developmental toxicity in rodents, four groups of Swiss (CD-1) mice were exposed to 0, 400, 1000 or 3000 ppM MEK vapors, 7 h/day, 7 dy/wk. Ten virgin females and approx.30 plug-positive females per group were exposed concurrently for 10 consecutive days (6--15 dg for mated mice). Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice on 18 dg. Uterine implants were enumerated and their status recorded. Live fetuses were sexed and examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. Exposure of pregnant mice to these concentrations of MEK did not result in apparent maternal toxicity, although there was a slight, treatment-correlated increase in liver to body weight ratios which was significant for the 3000-ppM group. Mild developmental toxicity was evident at 3000-ppM as a reduction in mean fetal body weight. This reduction was statistically significant for the males only, although the relative decrease in mean fetal body weight was the same for both sexes. 17 refs., 4 figs., 10 tabs. (ERA citation 14:025565)
Keywords	Mice Inhalation Prenatal Exposure Teratogenesis Toxicity Ketones Comparative Evaluations Dose-Response Relationships Life Span Litter Size Malformations Mortality Progress Report Sex Dependence Time Dependence Methyl ethyl ketone ERDA/560300 Concentration(Composition)
Source Agency	Technical Information Center Oak Ridge Tennessee
NTIS Subject Category	57Y - Toxicology 68G - Environmental Health & Safety 57E - Clinical Medicine
Corporate Authors	Battelle Pacific Northwest Labs., Richland, WA.; Department of Energy, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	198916
Contract Number	AC06-76RL01830