National Technical Reports Library

The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

Details

Reactions Connecting Autoxidation with Oxy Radical Production, Lipid Peroxidation, and Cytotoxicity.

DE83002220

Publication Date	1982
Personal Author	Borg, D. C.; Schaich, K. M.
Page Count	8
Abstract	A comprehensive scheme of autoxidative cytotoxicity is presented. Clarification of the direct reactions of O sub 2- and H sub 2 O with lipids and new evidence for copper-dependent catalysis of OH production is taken into account. The question is raised as to whether metal-independent reaction of H sub 2 O sub 2 might be significant in vivo. Emphasis is placed on the likely modes of propagating cytotoxicity at a distance. (ERA citation 08:006179)
Keywords	Radicals Cell membranes Oxidation Catalysis Toxicity Animal cells Lipids Copper Enzymes Biological pathways ERDA/550300 ERDA/560301
Source Agency	Technical Information Center Oak Ridge Tennessee
NTIS Subject Category	57Y - Toxicology 57F - Cytology, Genetics, & Molecular Biology
Corporate Authors	Brookhaven National Lab., Upton, NY.; Department of Energy, Washington, DC.
Supplemental Notes	International conference on superoxide and superoxide dismutase, Ellenville, NY, USA, 3 Oct 1982, Portions of document are illegible.
Document Type	Conference Proceedings
NTIS Issue Number	198311
Contract Number	AC02-76CH00016

Reactions Connecting Autoxidation with Oxy Radical Production, Lipid Peroxidation, and Cytotoxicity.

Reactions Connecting Autoxidation with Oxy Radical Production, Lipid Peroxidation, and Cytotoxicity.
DE83002220

Publication Date	1982
Personal Author	Borg, D. C.; Schaich, K. M.
Page Count	8
Abstract	A comprehensive scheme of autoxidative cytotoxicity is presented. Clarification of the direct reactions of O sub 2- and H sub 2 O with lipids and new evidence for copper-dependent catalysis of OH production is taken into account. The question is raised as to whether metal-independent reaction of H sub 2 O sub 2 might be significant in vivo. Emphasis is placed on the likely modes of propagating cytotoxicity at a distance. (ERA citation 08:006179)
Keywords	Radicals Cell membranes Oxidation Catalysis Toxicity Animal cells Lipids Copper Enzymes Biological pathways ERDA/550300 ERDA/560301
Source Agency	Technical Information Center Oak Ridge Tennessee
NTIS Subject Category	57Y - Toxicology 57F - Cytology, Genetics, & Molecular Biology
Corporate Authors	Brookhaven National Lab., Upton, NY.; Department of Energy, Washington, DC.
Supplemental Notes	International conference on superoxide and superoxide dismutase, Ellenville, NY, USA, 3 Oct 1982, Portions of document are illegible.
Document Type	Conference Proceedings
NTIS Issue Number	198311
Contract Number	AC02-76CH00016