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The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

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Investigation the 'Trojan Horse' Mechanism of Yersinia pestis Virulence.

DE2009957607

Publication Date	2005
Personal Author	McCutchen-Maloney, S. L.; Fitch, J. P.
Page Count	6
Abstract	This project focused on characterizing two novel mechanisms that regulate virulence factor induction in Y. pestis, immunoglobulin G (IgG) binding and quorum sensing, using a real-time reporter system to monitor induction of virulence. Incorporating a better understanding of the mechanisms of virulence and pathogenicity into detection systems, may allow us to anticipate both natural and engineered evolution of infectious diseases while laying the foundation for next-generation detection of biothreat agents.
Keywords	Virulence Yersinia pestis Immunoglobulins Immunity Induction Pathogens Monitoring Detection Infectious diseases Biological warfare agents
Source Agency	Technical Information Center Oak Ridge Tennessee
Corporate Authors	Lawrence Livermore National Lab., CA.; Department of Energy, Washington, DC.
Supplemental Notes	Sponsored by Department of Energy, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	200926
Contract Number	W-7405-ENG-48

Investigation the 'Trojan Horse' Mechanism of Yersinia pestis Virulence.

Investigation the 'Trojan Horse' Mechanism of Yersinia pestis Virulence.
DE2009957607

Publication Date	2005
Personal Author	McCutchen-Maloney, S. L.; Fitch, J. P.
Page Count	6
Abstract	This project focused on characterizing two novel mechanisms that regulate virulence factor induction in Y. pestis, immunoglobulin G (IgG) binding and quorum sensing, using a real-time reporter system to monitor induction of virulence. Incorporating a better understanding of the mechanisms of virulence and pathogenicity into detection systems, may allow us to anticipate both natural and engineered evolution of infectious diseases while laying the foundation for next-generation detection of biothreat agents.
Keywords	Virulence Yersinia pestis Immunoglobulins Immunity Induction Pathogens Monitoring Detection Infectious diseases Biological warfare agents
Source Agency	Technical Information Center Oak Ridge Tennessee
Corporate Authors	Lawrence Livermore National Lab., CA.; Department of Energy, Washington, DC.
Supplemental Notes	Sponsored by Department of Energy, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	200926
Contract Number	W-7405-ENG-48