National Technical Reports Library - NTRL

National Technical Reports Library

The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.




Details
Actions:
Download PDFDownload PDF
Download

Development of Chiral LC-MS Methods for Small Molecules and their Applications in the Analysis of Enantiomeric Composition and Pharmacokinetic Studies.


DE2005837266

Publication Date 2004
Personal Author Desai, M. J.
Page Count 172
Abstract The purpose of this research was to develop sensitive LC-MS methods for enantiomeric separation and detection, and then apply these methods for determination of enantiomeric composition and for the study of pharmacokinetic and pharmacodynamic properties of a chiral nutraceutical. Our first study, evaluated the use of reverse phase and polar organic mode for chiral LC-API/MS method development. Our second study, continued with chiral LC-MS method development in this case for the normal phase mode.
Keywords
  • Pharmacokinetics
  • Chromatography
  • Mass spectroscopy
  • Detection
  • Flow rate
  • Theses
  • Enantiomeric composition
  • Liquid chromatography-mass spectrometry(LC-MS)
  • Chiral LC-MS methods
  • Chiral nutraceutical
Source Agency
  • Technical Information Center Oak Ridge Tennessee
Corporate Authors Iowa State Univ., Ames.; Department of Energy, Washington, DC.
Supplemental Notes Sponsored by Department of Energy, Washington, DC.
Document Type Technical Report
NTIS Issue Number 200601
Development of Chiral LC-MS Methods for Small Molecules and their Applications in the Analysis of Enantiomeric Composition and Pharmacokinetic Studies.
Development of Chiral LC-MS Methods for Small Molecules and their Applications in the Analysis of Enantiomeric Composition and Pharmacokinetic Studies.
DE2005837266

  • Pharmacokinetics
  • Chromatography
  • Mass spectroscopy
  • Detection
  • Flow rate
  • Theses
  • Enantiomeric composition
  • Liquid chromatography-mass spectrometry(LC-MS)
  • Chiral LC-MS methods
  • Chiral nutraceutical
  • Technical Information Center Oak Ridge Tennessee
Loading