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Deletion of a Corodinate Regulator of Type 2 Cytokine Expression in Mice.

DE2005836370

Publication Date	2005
Personal Author	Mohrs, M.; Blakesppor, C. M.; Wang, Z. E.
Page Count	34
Abstract	Mechanisms underlying the differentiation of stable T helper subsets will be important in understanding how discrete types of immunity develop in response to different pathogens. An evolutionarily conserved approx. 400 base pair non-coding sequence in the IL- 4/IL-13 intergenic region, designated CNS-1, was deleted in mice. The capacity to develop Th2 cells was compromised in vitro and in vivo in the absence of CNS-1. Despite the profound effect in T cells, mast cells from CNS-1-deleted mice maintained their capacity to produce IL-4. A T cell-specific element critical for optimal expression of type 2 cytokines may represent evolution of a regulatory sequence exploited by adaptive immunity.
Keywords	Immunity Pathogens T cells Cytokines T lymphocytes Cells (Biology) Adaptive immunity
Source Agency	Technical Information Center Oak Ridge Tennessee
Corporate Authors	California Univ., San Francisco.; Department of Energy, Washington, DC.; Lawrence Berkeley National Lab., CA. Earth Sciences Division.
Supplemental Notes	Prepared in cooperation with Lawrence Berkeley National Lab., CA. Earth Sciences Division. Sponsored by Department of Energy, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	200520

Deletion of a Corodinate Regulator of Type 2 Cytokine Expression in Mice.

Deletion of a Corodinate Regulator of Type 2 Cytokine Expression in Mice.
DE2005836370

Publication Date	2005
Personal Author	Mohrs, M.; Blakesppor, C. M.; Wang, Z. E.
Page Count	34
Abstract	Mechanisms underlying the differentiation of stable T helper subsets will be important in understanding how discrete types of immunity develop in response to different pathogens. An evolutionarily conserved approx. 400 base pair non-coding sequence in the IL- 4/IL-13 intergenic region, designated CNS-1, was deleted in mice. The capacity to develop Th2 cells was compromised in vitro and in vivo in the absence of CNS-1. Despite the profound effect in T cells, mast cells from CNS-1-deleted mice maintained their capacity to produce IL-4. A T cell-specific element critical for optimal expression of type 2 cytokines may represent evolution of a regulatory sequence exploited by adaptive immunity.
Keywords	Immunity Pathogens T cells Cytokines T lymphocytes Cells (Biology) Adaptive immunity
Source Agency	Technical Information Center Oak Ridge Tennessee
Corporate Authors	California Univ., San Francisco.; Department of Energy, Washington, DC.; Lawrence Berkeley National Lab., CA. Earth Sciences Division.
Supplemental Notes	Prepared in cooperation with Lawrence Berkeley National Lab., CA. Earth Sciences Division. Sponsored by Department of Energy, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	200520