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Compact Gamma-Ray Imager for In-Vivo Gene Imaging. Final Report, September 14, 1999-March 4, 2000.

DE2005833940

Publication Date	2000
Personal Author	Greenwald, A. C.
Page Count	22
Abstract	A compact, low-cost, gamma-ray imaging system is needed to study gene expression in small animals. State-of-the-art electronic imaging systems have insufficient resolution and animals must be sacrificed for detailed imaging that precludes time evolution studies. With improved electronics radioactive tracers attached to gene markers can be used to track the absorption and mobility of gene therapy medications in live animals. Other instrumentation being developed for medical applications does not have the response to match the radiation source for this work. The objective of this research was to develop thick film (Cd,Zn)Te detectors matched to the gamma ray energy of (sup 129)I. The detector would be a direct readout device using p-i-n diodes formed from the high Z material absorbing the radiation, with separate readout. Higher quality semiconducting material was expected from epitaxial growth on GaAs, a near lattice matched substrate. In practice, it was difficult to obtain material with high resistance and low leakage current. Spire Corporation achieved the goal of fabricating working detectors in (Cd,Zn)Te deposited on GaAs. The spectra of an alpha emitter ((sup 225)Am) was adequately resolved in thin film devices. Thick p-i-n diodes were fabricated but other processing problems prevented full demonstration of a gamma ray detector.
Keywords	Genes In vivo Current Processing Thin films Gamma-ray imagers
Source Agency	Technical Information Center Oak Ridge Tennessee
Corporate Authors	Spire Corp., Bedford, MA.; Department of Energy, Argonne, IL. Chicago Operations Office.
Supplemental Notes	Sponsored by Department of Energy, Argonne, IL. Chicago Operations Office.
Document Type	Technical Report
NTIS Issue Number	200521

Compact Gamma-Ray Imager for In-Vivo Gene Imaging. Final Report, September 14, 1999-March 4, 2000.

Compact Gamma-Ray Imager for In-Vivo Gene Imaging. Final Report, September 14, 1999-March 4, 2000.
DE2005833940

Publication Date	2000
Personal Author	Greenwald, A. C.
Page Count	22
Abstract	A compact, low-cost, gamma-ray imaging system is needed to study gene expression in small animals. State-of-the-art electronic imaging systems have insufficient resolution and animals must be sacrificed for detailed imaging that precludes time evolution studies. With improved electronics radioactive tracers attached to gene markers can be used to track the absorption and mobility of gene therapy medications in live animals. Other instrumentation being developed for medical applications does not have the response to match the radiation source for this work. The objective of this research was to develop thick film (Cd,Zn)Te detectors matched to the gamma ray energy of (sup 129)I. The detector would be a direct readout device using p-i-n diodes formed from the high Z material absorbing the radiation, with separate readout. Higher quality semiconducting material was expected from epitaxial growth on GaAs, a near lattice matched substrate. In practice, it was difficult to obtain material with high resistance and low leakage current. Spire Corporation achieved the goal of fabricating working detectors in (Cd,Zn)Te deposited on GaAs. The spectra of an alpha emitter ((sup 225)Am) was adequately resolved in thin film devices. Thick p-i-n diodes were fabricated but other processing problems prevented full demonstration of a gamma ray detector.
Keywords	Genes In vivo Current Processing Thin films Gamma-ray imagers
Source Agency	Technical Information Center Oak Ridge Tennessee
Corporate Authors	Spire Corp., Bedford, MA.; Department of Energy, Argonne, IL. Chicago Operations Office.
Supplemental Notes	Sponsored by Department of Energy, Argonne, IL. Chicago Operations Office.
Document Type	Technical Report
NTIS Issue Number	200521