National Technical Reports Library

The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

Details

Microfluidic Tools for Biological Sample Preparation.

DE200515013423

Publication Date	2002
Personal Author	Visuri, S. R.; Ness, K.; Dzenitis, J.; Benett, B.; Bettencourt, K.; Hamilton, J.; Fisher, K.; Krulevitch, P.
Page Count	10
Abstract	Researchers at Lawrence Livermore National Laboratory are developing means to collect and identify fluid-based biological pathogens in the forms of proteins, viruses, and bacteria. To support detection instruments, we are developing a flexible fluidic sample preparation unit. The overall goal of this Microfluidic Module is to input a fluid sample, containing background particulates and potentially target compounds, and deliver a processed sample for detection. We are developing techniques for sample purification, mixing, and filtration that would be useful to many applications including immunologic and nucleic acid assays. Sample preparation functions are accomplished with acoustic radiation pressure, dielectrophoresis, and solid phase extraction. We are integrating these technologies into packaged systems with pumps and valves to control fluid flow and investigating small-scale detection methods.
Keywords	Microfluidic tools Dielectrophoresis Acoustics Collection Identification Nucleic acid Proteins Viruses Bacteria Modules Immunoassay Fluid-based biological pathogens Biological sample preparation Flexible fluidic sample preparation unit Lawrence Livermore National Laboratory
Source Agency	Technical Information Center Oak Ridge Tennessee
Corporate Authors	Lawrence Livermore National Lab., CA.; Department of Energy, Washington, DC.
Supplemental Notes	Sponsored by Department of Energy, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	200607

Microfluidic Tools for Biological Sample Preparation.

Microfluidic Tools for Biological Sample Preparation.
DE200515013423

Publication Date	2002
Personal Author	Visuri, S. R.; Ness, K.; Dzenitis, J.; Benett, B.; Bettencourt, K.; Hamilton, J.; Fisher, K.; Krulevitch, P.
Page Count	10
Abstract	Researchers at Lawrence Livermore National Laboratory are developing means to collect and identify fluid-based biological pathogens in the forms of proteins, viruses, and bacteria. To support detection instruments, we are developing a flexible fluidic sample preparation unit. The overall goal of this Microfluidic Module is to input a fluid sample, containing background particulates and potentially target compounds, and deliver a processed sample for detection. We are developing techniques for sample purification, mixing, and filtration that would be useful to many applications including immunologic and nucleic acid assays. Sample preparation functions are accomplished with acoustic radiation pressure, dielectrophoresis, and solid phase extraction. We are integrating these technologies into packaged systems with pumps and valves to control fluid flow and investigating small-scale detection methods.
Keywords	Microfluidic tools Dielectrophoresis Acoustics Collection Identification Nucleic acid Proteins Viruses Bacteria Modules Immunoassay Fluid-based biological pathogens Biological sample preparation Flexible fluidic sample preparation unit Lawrence Livermore National Laboratory
Source Agency	Technical Information Center Oak Ridge Tennessee
Corporate Authors	Lawrence Livermore National Lab., CA.; Department of Energy, Washington, DC.
Supplemental Notes	Sponsored by Department of Energy, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	200607