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Adaptive Response Against Spontaneous Neoplastic Transformation Induced by Low Dose Ionizing Radiation.

DE2004833309

Publication Date	2002
Page Count	50
Abstract	This project is being conducted to ascertain the shape of the dose response curve for neoplastic transformation in vitro over the dose range 0.0 to 10 cGy, and to determine how this depends on radiation quality and dose fractionation. Preliminary data already have indicated that at a dose of 1 cGy the induced transformation frequency is less than the spontaneous transformation frequency. The results will be compared with animal and human epidemiological data on the induction of cancer by low doses of radiation. This will hopefully allow for a more informed estimation of the risk of cancer induction at low doses.
Keywords	Neoplasms Ionizing radiations Transformations Animals Fractionated irradiation In vitro Induction Radiation quality Shape
Source Agency	Technical Information Center Oak Ridge Tennessee
Corporate Authors	Western Wisconsin Health Planning Organization, Inc., La Crosse.; Department of Energy, Washington, DC.
Supplemental Notes	Sponsored by Department of Energy, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	200514

Adaptive Response Against Spontaneous Neoplastic Transformation Induced by Low Dose Ionizing Radiation.

Adaptive Response Against Spontaneous Neoplastic Transformation Induced by Low Dose Ionizing Radiation.
DE2004833309

Publication Date	2002
Page Count	50
Abstract	This project is being conducted to ascertain the shape of the dose response curve for neoplastic transformation in vitro over the dose range 0.0 to 10 cGy, and to determine how this depends on radiation quality and dose fractionation. Preliminary data already have indicated that at a dose of 1 cGy the induced transformation frequency is less than the spontaneous transformation frequency. The results will be compared with animal and human epidemiological data on the induction of cancer by low doses of radiation. This will hopefully allow for a more informed estimation of the risk of cancer induction at low doses.
Keywords	Neoplasms Ionizing radiations Transformations Animals Fractionated irradiation In vitro Induction Radiation quality Shape
Source Agency	Technical Information Center Oak Ridge Tennessee
Corporate Authors	Western Wisconsin Health Planning Organization, Inc., La Crosse.; Department of Energy, Washington, DC.
Supplemental Notes	Sponsored by Department of Energy, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	200514