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DE2004828368

Publication Date	2000
Page Count	6
Abstract	The purpose of this study is to determine the bioavailability of organic solvents following dermal exposures to contaminated soil and water. Breath analysis is being used to obtain real-time measurements of volatile organics in expired air following exposure in rats and humans. Rhesus monkeys were used as surrogates for humans in benzene exposures. The exhaled breath data was analyzed using physiologically based pharmacokinetic (PBPK) models to determine the dermal bioavailability of organic solvents under realistic exposure conditions. The end product of this research will be a tested framework for the rapid screening of real and potential exposures while simultaneously developing PBPK models to comprehensively evaluate and compare exposures to organic compounds from either contaminated soil or water.
Keywords	Organic solvents Bioavailability Soils Materials Air Benzene Breath Macacus Organic compounds Risk assessment Water Dermal exposures
Source Agency	Technical Information Center Oak Ridge Tennessee
Corporate Authors	California Univ., San Francisco. Dept. of Dermatology.; Department of Energy, Washington, DC.; Pacific Northwest National Lab., Richland, WA.
Supplemental Notes	Prepared in cooperation with Pacific Northwest National Lab., Richland, WA. Sponsored by Department of Energy, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	200514

Bioavailability of Organic Solvents in Soils: Input into Biologically-Based Dose-Response Models for Human Risk Assessments.

Bioavailability of Organic Solvents in Soils: Input into Biologically-Based Dose-Response Models for Human Risk Assessments.
DE2004828368

Publication Date	2000
Page Count	6
Abstract	The purpose of this study is to determine the bioavailability of organic solvents following dermal exposures to contaminated soil and water. Breath analysis is being used to obtain real-time measurements of volatile organics in expired air following exposure in rats and humans. Rhesus monkeys were used as surrogates for humans in benzene exposures. The exhaled breath data was analyzed using physiologically based pharmacokinetic (PBPK) models to determine the dermal bioavailability of organic solvents under realistic exposure conditions. The end product of this research will be a tested framework for the rapid screening of real and potential exposures while simultaneously developing PBPK models to comprehensively evaluate and compare exposures to organic compounds from either contaminated soil or water.
Keywords	Organic solvents Bioavailability Soils Materials Air Benzene Breath Macacus Organic compounds Risk assessment Water Dermal exposures
Source Agency	Technical Information Center Oak Ridge Tennessee
Corporate Authors	California Univ., San Francisco. Dept. of Dermatology.; Department of Energy, Washington, DC.; Pacific Northwest National Lab., Richland, WA.
Supplemental Notes	Prepared in cooperation with Pacific Northwest National Lab., Richland, WA. Sponsored by Department of Energy, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	200514