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Feasibility of Positron Emission Tomography of Dose Distribution in Proton-Beam Cancer Therapy.

DE2003804610

Publication Date	2002
Personal Author	Beebe-Wang, J. J.; Dilmanian, F. A.; Peggs, S. G.; Schlyer, D. J.; Vaska, P.
Page Count	8
Abstract	Proton therapy is a treatment modality of increasing utility in clinical radiation oncology mostly because its dose distribution conforms more tightly to the target volume than x-ray radiation therapy. One important feature of proton therapy is that it produces a small amount of positron-emitting isotopes along the beam-path through the non-elastic nuclear interaction of protons with target nuclei. These radioisotopes allow imaging the therapy dose distribution using positron emission tomography (PET). The resulting PET images provide a powerful tool for quality assurance of the treatment, especially when treating inhomogeneous organs such as the lungs or the head-and-neck, where the calculation of the dose distribution for treatment planning is more difficult. This paper uses Monte Carlo simulations to predict the yield of positron emitters produced by a 250 MeV proton beam, and to simulate the productions of the image in a clinical PET scanner.
Keywords	Positrons Proton beams Tomography Radiation doses Cancer Radiotherapy Lungs Neoplasms Nuclei Radioisotopes Quality assurance Therapy Dose distributions Monte Carlo method Targets Positron emission tomography(PET)
Source Agency	Technical Information Center Oak Ridge Tennessee
Corporate Authors	Brookhaven National Lab., Upton, NY.; Department of Energy, Washington, DC.
Supplemental Notes	Sponsored by Department of Energy, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	200313

Feasibility of Positron Emission Tomography of Dose Distribution in Proton-Beam Cancer Therapy.

Feasibility of Positron Emission Tomography of Dose Distribution in Proton-Beam Cancer Therapy.
DE2003804610

Publication Date	2002
Personal Author	Beebe-Wang, J. J.; Dilmanian, F. A.; Peggs, S. G.; Schlyer, D. J.; Vaska, P.
Page Count	8
Abstract	Proton therapy is a treatment modality of increasing utility in clinical radiation oncology mostly because its dose distribution conforms more tightly to the target volume than x-ray radiation therapy. One important feature of proton therapy is that it produces a small amount of positron-emitting isotopes along the beam-path through the non-elastic nuclear interaction of protons with target nuclei. These radioisotopes allow imaging the therapy dose distribution using positron emission tomography (PET). The resulting PET images provide a powerful tool for quality assurance of the treatment, especially when treating inhomogeneous organs such as the lungs or the head-and-neck, where the calculation of the dose distribution for treatment planning is more difficult. This paper uses Monte Carlo simulations to predict the yield of positron emitters produced by a 250 MeV proton beam, and to simulate the productions of the image in a clinical PET scanner.
Keywords	Positrons Proton beams Tomography Radiation doses Cancer Radiotherapy Lungs Neoplasms Nuclei Radioisotopes Quality assurance Therapy Dose distributions Monte Carlo method Targets Positron emission tomography(PET)
Source Agency	Technical Information Center Oak Ridge Tennessee
Corporate Authors	Brookhaven National Lab., Upton, NY.; Department of Energy, Washington, DC.
Supplemental Notes	Sponsored by Department of Energy, Washington, DC.
Document Type	Technical Report
NTIS Issue Number	200313