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Development and Evaluation of Rhenium-188-labeled Radioactive Stents for Restenosis Therapy and Development of Strategies for Radiolabeling Brachytherapy Sources with Palladium-103.


DE2001786765

Publication Date 2001
Personal Author Knapp, F. F.
Page Count 10
Abstract This project involved collaboration between InnerDyne, Inc., and radiopharmaceutical research programs at the Oak Ridge National Laboratory (ORNL) and Brookhaven National Laboratory (BNL) which explored new strategies for the development and animal testing of radioactive rhenium-188-labeled implantable stent sources for the treatment of coronary restenosis after angioplasty and the development of chemical species radiolabeled with the palladium-103 radioisotope for the treatment of cancer. Rhenium-188 was made available for these studies from radioactive decay of tungsten-188 produced in the ORNL High Flux Isotope Reactor (HFIR). Stent activation and coating technology was developed and provided by InnerDyne, inc. New chemical methods for attaching the palladium-103 radioisotope to bifunctional chelate technologies were developed by investigators at ORNL.
Keywords
  • Drugs
  • Pharmacology
  • Isotopic labelling
  • Rhenium isotopes
  • Palladium isotopes
  • Stents
  • Cardiology
  • Cardiovascular diseases
Source Agency
  • Technical Information Center Oak Ridge Tennessee
Corporate Authors Oak Ridge National Lab., TN.; Department of Energy, Washington, DC.
Document Type Technical Report
NTIS Issue Number 200201
Contract Number
  • AC05-00OR22725
Development and Evaluation of Rhenium-188-labeled Radioactive Stents for Restenosis Therapy and Development of Strategies for Radiolabeling Brachytherapy Sources with Palladium-103.
Development and Evaluation of Rhenium-188-labeled Radioactive Stents for Restenosis Therapy and Development of Strategies for Radiolabeling Brachytherapy Sources with Palladium-103.
DE2001786765

  • Drugs
  • Pharmacology
  • Isotopic labelling
  • Rhenium isotopes
  • Palladium isotopes
  • Stents
  • Cardiology
  • Cardiovascular diseases
  • Technical Information Center Oak Ridge Tennessee
  • AC05-00OR22725
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