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Tailoring x-ray beam energy spectrum to enhance image quality of new radiography contrast agents based on gd or other lanthanides.

DE2001781370

Publication Date	2001
Personal Author	Dilmanian, ; Weinmann, ; Zhong, ; Bacarian, ; Rigon,
Page Count	10
Abstract	Gadovist, a 1.0-molar Gd contrast agent from Schering AG, Berlin Germany, in use in clinical MPI in Europe, was evaluated as a radiography contrast agent. In a collaboration with Brookhaven National Laboratory (BNL), Schering AG is developing several such lanthanide-based contrast agents, while BNL evaluates them using different x-my beam energy spectra. These energy spectra include a 'truly' monochromatic beam (0.2 keV energy bandwidth) from the National Synchrotron Light Source (NSLS), BNL, tuned above the Gd K-edge, and x-ray-tube beams from different kVp settings and beam filtrations. Radiographs of rabbits' kidneys were obtained with Gadovist at the NSLS. Furthermore, a clinical radiography system was used for imaging rabbits' kidneys comparing Gadovist and Conray, an iodinated contrast agent. The study, using 74 kVp and standard Al beam filter for Conray and 66 kVp and an additional 1.5 mm Cu beam filter for Gadovist, produced comparable images for Gadovist and Conray; the injection volumes were the same, while the radiation absorbed dose for Gadovist was slightly smaller. A bent-crystal silicon monochromator operating in the Laue diffraction mode was developed and tested with a conventional x-ray tube beam; it narrows the energy spectrum to about 4 keV around the anode tungsten's Ku line. Preliminary beam-flux results indicate that the method could be implemented in clinical CT if x-ray tubes with (approximately) twice higher output become available.
Keywords	Contrast media Biomedical radiography Gadolinium Energy spectra Images Radiation doses Rare earths X-ray tubes Rabbits Kidneys
Source Agency	Technical Information Center Oak Ridge Tennessee
Corporate Authors	Brookhaven National Lab., Upton, NY.; Department of Energy, Washington, DC.
Document Type	Conference Proceedings
NTIS Issue Number	200125
Contract Number	AC02-98CH10886

Tailoring x-ray beam energy spectrum to enhance image quality of new radiography contrast agents based on gd or other lanthanides.

Tailoring x-ray beam energy spectrum to enhance image quality of new radiography contrast agents based on gd or other lanthanides.
DE2001781370

Publication Date	2001
Personal Author	Dilmanian, ; Weinmann, ; Zhong, ; Bacarian, ; Rigon,
Page Count	10
Abstract	Gadovist, a 1.0-molar Gd contrast agent from Schering AG, Berlin Germany, in use in clinical MPI in Europe, was evaluated as a radiography contrast agent. In a collaboration with Brookhaven National Laboratory (BNL), Schering AG is developing several such lanthanide-based contrast agents, while BNL evaluates them using different x-my beam energy spectra. These energy spectra include a 'truly' monochromatic beam (0.2 keV energy bandwidth) from the National Synchrotron Light Source (NSLS), BNL, tuned above the Gd K-edge, and x-ray-tube beams from different kVp settings and beam filtrations. Radiographs of rabbits' kidneys were obtained with Gadovist at the NSLS. Furthermore, a clinical radiography system was used for imaging rabbits' kidneys comparing Gadovist and Conray, an iodinated contrast agent. The study, using 74 kVp and standard Al beam filter for Conray and 66 kVp and an additional 1.5 mm Cu beam filter for Gadovist, produced comparable images for Gadovist and Conray; the injection volumes were the same, while the radiation absorbed dose for Gadovist was slightly smaller. A bent-crystal silicon monochromator operating in the Laue diffraction mode was developed and tested with a conventional x-ray tube beam; it narrows the energy spectrum to about 4 keV around the anode tungsten's Ku line. Preliminary beam-flux results indicate that the method could be implemented in clinical CT if x-ray tubes with (approximately) twice higher output become available.
Keywords	Contrast media Biomedical radiography Gadolinium Energy spectra Images Radiation doses Rare earths X-ray tubes Rabbits Kidneys
Source Agency	Technical Information Center Oak Ridge Tennessee
Corporate Authors	Brookhaven National Lab., Upton, NY.; Department of Energy, Washington, DC.
Document Type	Conference Proceedings
NTIS Issue Number	200125
Contract Number	AC02-98CH10886