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Incorporation of Lung Surfactant Specific Protein SP-B into Lipid Monolayers at the Air-Fluid Interface: A Grazing Incidence X-ray Diffraction Study.

DE2001763300

Publication Date	2000
Personal Author	Lee, K.; Majewski, J.
Page Count	9
Abstract	Lung surfactant (LS), a complex mixture of lipids and proteins, lines the alveoli, and is responsible for the proper functioning of the lung (1). LS works both by lowering the surface tension inside the lungs to reduce the work of breathing, and by stabilizing the alveoli through varying the surface tension as a function of alveolar volume. To accomplish this, the LS mixture must adsorb rapidly to the air-fluid interface of the alveoli after being secreted. Once at the interface, it must form a monolayer that can both achieve low surface tensions upon compression and vary the surface tension as a function of the alveolar radius. Insufficient levels of surfactant, due to either immaturity in premature infants, and disease or trauma in adults, can result in respiratory distress syndrome (RDS), a potentially lethal disease in both populations.
Keywords	Lipids Lungs Proteins Air fluids Diseases Respiratory distress syndrome Surfactants
Source Agency	Technical Information Center Oak Ridge Tennessee
NTIS Subject Category	57B - Biochemistry 57E - Clinical Medicine
Corporate Authors	Los Alamos National Lab., NM.; Department of Energy, Washington, DC.
Document Type	Conference Proceedings
NTIS Issue Number	200123
Contract Number	W-7405-ENG-36

Incorporation of Lung Surfactant Specific Protein SP-B into Lipid Monolayers at the Air-Fluid Interface: A Grazing Incidence X-ray Diffraction Study.

Incorporation of Lung Surfactant Specific Protein SP-B into Lipid Monolayers at the Air-Fluid Interface: A Grazing Incidence X-ray Diffraction Study.
DE2001763300

Publication Date	2000
Personal Author	Lee, K.; Majewski, J.
Page Count	9
Abstract	Lung surfactant (LS), a complex mixture of lipids and proteins, lines the alveoli, and is responsible for the proper functioning of the lung (1). LS works both by lowering the surface tension inside the lungs to reduce the work of breathing, and by stabilizing the alveoli through varying the surface tension as a function of alveolar volume. To accomplish this, the LS mixture must adsorb rapidly to the air-fluid interface of the alveoli after being secreted. Once at the interface, it must form a monolayer that can both achieve low surface tensions upon compression and vary the surface tension as a function of the alveolar radius. Insufficient levels of surfactant, due to either immaturity in premature infants, and disease or trauma in adults, can result in respiratory distress syndrome (RDS), a potentially lethal disease in both populations.
Keywords	Lipids Lungs Proteins Air fluids Diseases Respiratory distress syndrome Surfactants
Source Agency	Technical Information Center Oak Ridge Tennessee
NTIS Subject Category	57B - Biochemistry 57E - Clinical Medicine
Corporate Authors	Los Alamos National Lab., NM.; Department of Energy, Washington, DC.
Document Type	Conference Proceedings
NTIS Issue Number	200123
Contract Number	W-7405-ENG-36