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Skin Decontamination of G, V, H L Agents by Canadian Reactive Skin Decontaminant Lotion.

ADP008793

Publication Date	1993
Personal Author	Bide, R. W.; Sawyer, T. W.; DiNinno, V. L.; Armour, S. J.; Risk, D. J.
Page Count	10
Abstract	The Canadian Reactive Skin Decontaminant Lotion (RSDL) is a reactive solution designed to be applied directly to skin for the decontamination and destruction of the classical chemical warfare agents. The solvent of the RSDL is very effective in dissolving liquid agents from the skin surface and the differential solubility of agents in the RSDL and the skin strongly favors retention of agents in the lotion. The active ingredient in the RSDL reacts rapidly and completely with G-agents, V-agents, mustard Lewisite producing relatively nontoxic products. The RSDL will dissolve and destroy agent thickened with acrylate polymers. The lotion is water soluble and readily removed from the skin. Since the RSDL is water soluble, it is active against water soluble agents even at high dilutions. For water insoluble agents, the activity is reduced as the water content rises above abrasive 50% due to insolubility of the agents. Skin and eye irritancy trials indicate that the RSDL is only a mild irritant to the eyes (equivalent to a chlorinated swimming pool) and to abraded skin. Acute toxicity trials showed that large oral and intraperitoneal doses were essentially non-toxic. The RSDL was fielded by the Canadian Forces for the Gulf Conflict. The RSDL may be used in open wounds for short periods. Wound decontamination and irrigation with RSDL diluted 1:1 with isotonic saline was recommended for the Gulf conflict.
Keywords	Decontamination materials Chemical warfare agents Decontamination Acrylates Dissolving G agents Lewisite Liquids Solubility Toxicity V agents Water Foreign technology Lotions Component Reports
Source Agency	Non Paid ADAS
NTIS Subject Category	57Q - Pharmacology & Pharmacological Chemistry 57Y - Toxicology 74D - Chemical, Biological, & Radiological Warfare
Corporate Authors	Defence Research Establishment Suffield, Ralston (Alberta).
Supplemental Notes	This article is from 'Proceedings of the Medical Defense Bioscience Review (1993) Held in Baltimore, Maryland on 10-13 May 1993. Volume 1', AD-A275 667, p379-387.
Document Type	Technical Report
NTIS Issue Number	199413

Skin Decontamination of G, V, H L Agents by Canadian Reactive Skin Decontaminant Lotion.

Skin Decontamination of G, V, H L Agents by Canadian Reactive Skin Decontaminant Lotion.
ADP008793

Publication Date	1993
Personal Author	Bide, R. W.; Sawyer, T. W.; DiNinno, V. L.; Armour, S. J.; Risk, D. J.
Page Count	10
Abstract	The Canadian Reactive Skin Decontaminant Lotion (RSDL) is a reactive solution designed to be applied directly to skin for the decontamination and destruction of the classical chemical warfare agents. The solvent of the RSDL is very effective in dissolving liquid agents from the skin surface and the differential solubility of agents in the RSDL and the skin strongly favors retention of agents in the lotion. The active ingredient in the RSDL reacts rapidly and completely with G-agents, V-agents, mustard Lewisite producing relatively nontoxic products. The RSDL will dissolve and destroy agent thickened with acrylate polymers. The lotion is water soluble and readily removed from the skin. Since the RSDL is water soluble, it is active against water soluble agents even at high dilutions. For water insoluble agents, the activity is reduced as the water content rises above abrasive 50% due to insolubility of the agents. Skin and eye irritancy trials indicate that the RSDL is only a mild irritant to the eyes (equivalent to a chlorinated swimming pool) and to abraded skin. Acute toxicity trials showed that large oral and intraperitoneal doses were essentially non-toxic. The RSDL was fielded by the Canadian Forces for the Gulf Conflict. The RSDL may be used in open wounds for short periods. Wound decontamination and irrigation with RSDL diluted 1:1 with isotonic saline was recommended for the Gulf conflict.
Keywords	Decontamination materials Chemical warfare agents Decontamination Acrylates Dissolving G agents Lewisite Liquids Solubility Toxicity V agents Water Foreign technology Lotions Component Reports
Source Agency	Non Paid ADAS
NTIS Subject Category	57Q - Pharmacology & Pharmacological Chemistry 57Y - Toxicology 74D - Chemical, Biological, & Radiological Warfare
Corporate Authors	Defence Research Establishment Suffield, Ralston (Alberta).
Supplemental Notes	This article is from 'Proceedings of the Medical Defense Bioscience Review (1993) Held in Baltimore, Maryland on 10-13 May 1993. Volume 1', AD-A275 667, p379-387.
Document Type	Technical Report
NTIS Issue Number	199413