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Terahertz Radiation: A Non-contact Tool for the Selective Stimulation of Biological Responses in Human Cells.

ADA631799

Publication Date	2014
Personal Author	Echchgadda, I.; Grundt, J. E.; Cerna, C. Z.; Roth, C. C.; Payne, J. A.; Ibey, B. L.; Wilmink, G. J.
Page Count	16
Abstract	Collective motions of water and of many biological macromolecules have characteristic time scales on the order of a picosecond. As a result, these biomolecules can strongly absorb terahertz (THz) radiation. Due to this absorption, THz radiation can exert a diverse range of effects on biological structures. For example, THz radiation has been shown to impact the structure, functional activity, and dynamics of macromolecules such as deoxyribonucleic acid (DNA) and proteins. THz-molecular interactions can affect several gene expression pathways and, consequently, can alter various biochemical and physiological processes in cells. Indeed, THz radiation has been shown to influence the expression of several genes within different cell types. However, a complete view of the global transcriptional responses and the intracellular canonical pathways specifically triggered by THz radiation has not been elucidated. In this study, we performed a global profiling of transcripts in human cells exposed to 2.52 THz radiation and compared the exposure responses to a thermally-matched bulk-heating (BH) protocol. Our results show that both THz radiation and BH induce a significant change in the expression of numerous messenger ribonucleic acid (mRNA) and microRNAs (miRNAs). The data also show that THz radiation triggers specific intracellular canonical pathways that are not affected in the BH-exposed cells. This study implies that THz radiation may be a useful, non-contact tool for the selective control of specific genes and cellular processes.
Keywords	Cells(biology) Radiation Response(biology) Stimulation(physiology) Biochemistry Biomolecules Cytology Deoxyribonucleic acids Exposure(physiology) Gene expression Heating Ribonucleic acids Transcription(genetics) Cell exposure Cellular response Global gene expression Mirnas(micrornas) Mrnas Signaling pathways Thermal effect Thz bioeffect Thz(terahertz) Bh(bulk heating) Pe62202f Wuafrlhoeb
Source Agency	Non Paid ADAS
NTIS Subject Category	57B - Biochemistry 57A - Anatomy 57S - Physiology 57E - Clinical Medicine
Corporate Authors	Air Force Research Lab., Wright-Patterson AFB, OH. Human Performance Wing (711th).
Document Type	Technical Report
Title Note	Journal article
NTIS Issue Number	201619
Contract Number	FA8650-07-D-6800-0001

Terahertz Radiation: A Non-contact Tool for the Selective Stimulation of Biological Responses in Human Cells.

Terahertz Radiation: A Non-contact Tool for the Selective Stimulation of Biological Responses in Human Cells.
ADA631799

Publication Date	2014
Personal Author	Echchgadda, I.; Grundt, J. E.; Cerna, C. Z.; Roth, C. C.; Payne, J. A.; Ibey, B. L.; Wilmink, G. J.
Page Count	16
Abstract	Collective motions of water and of many biological macromolecules have characteristic time scales on the order of a picosecond. As a result, these biomolecules can strongly absorb terahertz (THz) radiation. Due to this absorption, THz radiation can exert a diverse range of effects on biological structures. For example, THz radiation has been shown to impact the structure, functional activity, and dynamics of macromolecules such as deoxyribonucleic acid (DNA) and proteins. THz-molecular interactions can affect several gene expression pathways and, consequently, can alter various biochemical and physiological processes in cells. Indeed, THz radiation has been shown to influence the expression of several genes within different cell types. However, a complete view of the global transcriptional responses and the intracellular canonical pathways specifically triggered by THz radiation has not been elucidated. In this study, we performed a global profiling of transcripts in human cells exposed to 2.52 THz radiation and compared the exposure responses to a thermally-matched bulk-heating (BH) protocol. Our results show that both THz radiation and BH induce a significant change in the expression of numerous messenger ribonucleic acid (mRNA) and microRNAs (miRNAs). The data also show that THz radiation triggers specific intracellular canonical pathways that are not affected in the BH-exposed cells. This study implies that THz radiation may be a useful, non-contact tool for the selective control of specific genes and cellular processes.
Keywords	Cells(biology) Radiation Response(biology) Stimulation(physiology) Biochemistry Biomolecules Cytology Deoxyribonucleic acids Exposure(physiology) Gene expression Heating Ribonucleic acids Transcription(genetics) Cell exposure Cellular response Global gene expression Mirnas(micrornas) Mrnas Signaling pathways Thermal effect Thz bioeffect Thz(terahertz) Bh(bulk heating) Pe62202f Wuafrlhoeb
Source Agency	Non Paid ADAS
NTIS Subject Category	57B - Biochemistry 57A - Anatomy 57S - Physiology 57E - Clinical Medicine
Corporate Authors	Air Force Research Lab., Wright-Patterson AFB, OH. Human Performance Wing (711th).
Document Type	Technical Report
Title Note	Journal article
NTIS Issue Number	201619
Contract Number	FA8650-07-D-6800-0001