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Novel Predictors of Sepsis Outperform the American Burn Association Sepsis Criteria in the Burn Intensive Care Unit Patient.

ADA615150

Publication Date	2013
Personal Author	Mann-Salinas, E. A.; Baun, M. M.; Meininger, J. C.; Murray, C. K.; Aden, J. K.; Wolf, S. E.; Wade, C. E.
Page Count	14
Abstract	The purpose of this study was to determine whether systemic inflammatory response syndrome (SIRS) and American Burn Association (ABA) criteria predict sepsis in the burn patient and develop a model representing the best combination of novel clinical sepsis predictors. A retrospective, case-controlled, within-patient comparison of burn patients admitted to a single intensive care unit from January 2005 to September 2010 was made. Blood culture results were paired with documented sepsis: positive-sick, negative-sick (collectively defined as sick), and negative-not sick. Data for all predictors were collected for the 72 hours before blood culture. Variables were evaluated using regression and area under the curve (AUC) analyses. Fifty-nine subjects represented 177 culture periods. SIRS criteria were not discriminative: 98% of the subjects met criteria. ABA sepsis criteria were different on the day before (P =.004). The six best-fit variables identified for the model included heart rate greater than 130 beats per min, mean arterial pressure less than 60 mm Hg, base deficit less than 6 mEq/L, temperature less than 36 degrees Celsius, use of vasoactive medications, and glucose greater than 150 mg/dl. The model was significant in predicting positive-sick and sick, with an AUC of 0.775 (P less than .001) and 0.714 (P less than .001), respectively; comparatively, the ABA criteria AUC was 0.619 (P = .028) and 0.597 (P= .035), respectively. Usefulness of the ABA criteria to predict sepsis is limited to the day before blood culture is obtained. A significant contribution of this research is the identification of six novel sepsis predictors for the burn patient.
Keywords	BURNS(INJURIES) INTENSIVE CARE UNITS PATIENTS SEPSIS BACTEREMIA BLOOD PRESSURE CASE STUDIES CLINICAL MEDICINE CULTURES(BIOLOGY) DIAGNOSIS(MEDICINE) EFFICIENCY IDENTIFICATION INFLAMMATION MEDICAL PERSONNEL MODELS MORTALITY RATE PATHOGENESIS PREDICTIONS REGRESSION ANALYSIS RESPONSE(BIOLOGY) STANDARDS TRAUMA SIRS(SYSTEMIC INFLAMMATORY RESPONSE SYNDROME) ABA(AMERICAN BURN ASSOCIATION) AUC(AREA UNDER THE CURVE) MODS(MULTIPLE ORGAN FAILURE SYNDROME) HR(HEART RATE) SEPSIS CRITERIA
Source Agency	Non Paid ADAS
NTIS Subject Category	57E - Clinical Medicine
Corporate Authors	Army Inst. of Surgical Research, Fort Sam Houston, TX.
Supplemental Notes	Published in the Journal of Burn Care & Research, v31 n1 p31-43, January/February 2013.
Document Type	Technical Report
Title Note	Journal article
NTIS Issue Number	201518
Contract Number	HU0001-10 1-TS06

Novel Predictors of Sepsis Outperform the American Burn Association Sepsis Criteria in the Burn Intensive Care Unit Patient.

Novel Predictors of Sepsis Outperform the American Burn Association Sepsis Criteria in the Burn Intensive Care Unit Patient.
ADA615150

Publication Date	2013
Personal Author	Mann-Salinas, E. A.; Baun, M. M.; Meininger, J. C.; Murray, C. K.; Aden, J. K.; Wolf, S. E.; Wade, C. E.
Page Count	14
Abstract	The purpose of this study was to determine whether systemic inflammatory response syndrome (SIRS) and American Burn Association (ABA) criteria predict sepsis in the burn patient and develop a model representing the best combination of novel clinical sepsis predictors. A retrospective, case-controlled, within-patient comparison of burn patients admitted to a single intensive care unit from January 2005 to September 2010 was made. Blood culture results were paired with documented sepsis: positive-sick, negative-sick (collectively defined as sick), and negative-not sick. Data for all predictors were collected for the 72 hours before blood culture. Variables were evaluated using regression and area under the curve (AUC) analyses. Fifty-nine subjects represented 177 culture periods. SIRS criteria were not discriminative: 98% of the subjects met criteria. ABA sepsis criteria were different on the day before (P =.004). The six best-fit variables identified for the model included heart rate greater than 130 beats per min, mean arterial pressure less than 60 mm Hg, base deficit less than 6 mEq/L, temperature less than 36 degrees Celsius, use of vasoactive medications, and glucose greater than 150 mg/dl. The model was significant in predicting positive-sick and sick, with an AUC of 0.775 (P less than .001) and 0.714 (P less than .001), respectively; comparatively, the ABA criteria AUC was 0.619 (P = .028) and 0.597 (P= .035), respectively. Usefulness of the ABA criteria to predict sepsis is limited to the day before blood culture is obtained. A significant contribution of this research is the identification of six novel sepsis predictors for the burn patient.
Keywords	BURNS(INJURIES) INTENSIVE CARE UNITS PATIENTS SEPSIS BACTEREMIA BLOOD PRESSURE CASE STUDIES CLINICAL MEDICINE CULTURES(BIOLOGY) DIAGNOSIS(MEDICINE) EFFICIENCY IDENTIFICATION INFLAMMATION MEDICAL PERSONNEL MODELS MORTALITY RATE PATHOGENESIS PREDICTIONS REGRESSION ANALYSIS RESPONSE(BIOLOGY) STANDARDS TRAUMA SIRS(SYSTEMIC INFLAMMATORY RESPONSE SYNDROME) ABA(AMERICAN BURN ASSOCIATION) AUC(AREA UNDER THE CURVE) MODS(MULTIPLE ORGAN FAILURE SYNDROME) HR(HEART RATE) SEPSIS CRITERIA
Source Agency	Non Paid ADAS
NTIS Subject Category	57E - Clinical Medicine
Corporate Authors	Army Inst. of Surgical Research, Fort Sam Houston, TX.
Supplemental Notes	Published in the Journal of Burn Care & Research, v31 n1 p31-43, January/February 2013.
Document Type	Technical Report
Title Note	Journal article
NTIS Issue Number	201518
Contract Number	HU0001-10 1-TS06