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Electrospray LC/MS Detection of EA 2192 in Aqueous Solution.

ADA382406

Publication Date	2000
Personal Author	Rohrbaugh, D. K.; Elizy, M. W.
Page Count	19
Abstract	This report describes efforts to detect EA 2192, S-2- (DIISOPROPYLAMINO)ETHYL methylphosphonothioic acid, in aqueous solutions below the drinking water standard level of 20 ppb. LC/MS electrospray ionization and tandem MS detection using a parent ion of 240 m/z and a product ion of 128 m/z were applied to obtain the desired analytical sensitivity, selectivity, and reproducibility. From replicate analyses of a 10-ppb standard, a method detection limit (MDL) of 1-2 ppb in water was obtained. The method was also applied to EA 2192 detection in aqueous charcoal extract with similar results. Additional sample cleanup to remove interference is required, however, before the method can be applied to more complex decontamination matrices.
Keywords	Decontamination Vx agent Liquid chromatography Chemical ordnance Chemical agent detectors Vesicants Mass spectrometry Aqueous solutions Ea 2192 Electrospray ionization Diisopropylamino-ethyl- methylphosphonothioic acid Mdl(Method detection limit)
Source Agency	Non Paid ADAS
NTIS Subject Category	74D - Chemical, Biological, & Radiological Warfare
Corporate Authors	Edgewood Chemical Biological Center, Aberdeen Proving Ground, MD.
Document Type	Technical Report
Title Note	Final rept. Sep-Dec 1999.
NTIS Issue Number	200102

Electrospray LC/MS Detection of EA 2192 in Aqueous Solution.

Electrospray LC/MS Detection of EA 2192 in Aqueous Solution.
ADA382406

Publication Date	2000
Personal Author	Rohrbaugh, D. K.; Elizy, M. W.
Page Count	19
Abstract	This report describes efforts to detect EA 2192, S-2- (DIISOPROPYLAMINO)ETHYL methylphosphonothioic acid, in aqueous solutions below the drinking water standard level of 20 ppb. LC/MS electrospray ionization and tandem MS detection using a parent ion of 240 m/z and a product ion of 128 m/z were applied to obtain the desired analytical sensitivity, selectivity, and reproducibility. From replicate analyses of a 10-ppb standard, a method detection limit (MDL) of 1-2 ppb in water was obtained. The method was also applied to EA 2192 detection in aqueous charcoal extract with similar results. Additional sample cleanup to remove interference is required, however, before the method can be applied to more complex decontamination matrices.
Keywords	Decontamination Vx agent Liquid chromatography Chemical ordnance Chemical agent detectors Vesicants Mass spectrometry Aqueous solutions Ea 2192 Electrospray ionization Diisopropylamino-ethyl- methylphosphonothioic acid Mdl(Method detection limit)
Source Agency	Non Paid ADAS
NTIS Subject Category	74D - Chemical, Biological, & Radiological Warfare
Corporate Authors	Edgewood Chemical Biological Center, Aberdeen Proving Ground, MD.
Document Type	Technical Report
Title Note	Final rept. Sep-Dec 1999.
NTIS Issue Number	200102