| Publication Date |
2000 |
| Personal Author |
Reutter, S. A.; Mioduszewski, R. J.; Thomson, S. A. |
| Page Count |
85 |
| Abstract |
Existing occupational airborne exposure limits (now referred to as 'worker population limits' or WPLs) and general population airborne exposure limits (now referred to as 'general population limits' or GPLs) were reviewed and recalculated using current risk assessment methods and two sets of data not considered in previous estimates. These 'newer' data resulted in estimated WPLs and GPLs lower than existing values. However, the quality of both sets of data was such that there was not sufficient confidence to select either as a critical study. Overall, the quality and quantity of the data for VX are less than desirable. In addition, no chronic studies have been done. Given this, it was decided to develop the exposure limits for VX relative to those for GB. A potency ratio of 10 was selected, based upon relative potencies of GB and VX in producing miosis. (It was noted, however, that unlike GB, VX vapor is a percutaneous hazard, and the relative potency ratio for threshold percutaneous effects is about 100.) Based upon the miosis potency ratio, the existing WPL for VX (0.00001 mg/m3) was deemed adequately protective. However, the existing GPL was not, and a concentration of 0.0000003 mg/m3 is recommended. The existing immediately dangerous to life or health (IDLH) exposure level for occupational workers was recalculated relative to that for GB. A value of 0.01 mg/m3 is recommended. A short-term exposure limit (STEL), for workers, was developed relative to that for GB. The recommended value is 0.00004 mg/m3, for up to four 15-minute exposures per day. |
| Keywords |
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| Source Agency |
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| NTIS Subject Category |
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| Corporate Authors |
Edgewood Chemical Biological Center, Aberdeen Proving Ground, MD. |
| Document Type |
Technical Report |
| Title Note |
Final rept. Jun 1997-Oct 1999. |
| NTIS Issue Number |
200015 |
| Contract Number |
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