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Acute and Subacute Toxicity Evaluation of Ammonium Dinitramide.

ADA298965

Publication Date	1994
Personal Author	Kinkead, E. R.; Salins, S. A.; Wolfe, R. E.; Marit, G. B.
Page Count	17
Abstract	The Department of Defense is considering replacing ammonium perchiorate with ammonium dinitramide (ADN). Ammonium dinitramide, a Class 1.1 explosive oxidizer, would be used in solid rocket engine propellant mixtures as well as used as a high explosive. The first objective of this study was to provide acute hazard information on ADN to industrial hygienists responsible for the safe handling of this material. Because the most likely form of accidental exposure would be by the dermal or oral routes, acute oral and dermal toxicity tests were performed. Oral gavage of ADN solutions greater than 1 g/kg resulted in mortality preceded by convulsions. An oral LD50 of 823 mg/kg was determined for male Fischer 344 rats. Rats receiving nonlethal doses of ADN showed no treatment-related effects when necropsied following a 14-day observation period. Dermal toxicity in New Zealand white rabbits, performed at the Environmental Protection Agency's limit dose level of 2 g/kg body weight, resulted in no mortality, no clinical signs or differences in clinical pathology following a 14-day post-treatment observation period.
Keywords	Toxicity Skin(Anatomy) Ammonium perchlorate Test and evaluation Department of defense Hazards Exposure(General) Rats Test methods Clinical medicine Signs and symptoms Safety Specialists Handling High explosives Industrial hygiene Oral intake Rabbits White(Color) Accidents Convulsive disorders Dermatology New zealand Ammonium dinitramide Dermal toxicity Oral gavage
Source Agency	Non Paid ADAS
NTIS Subject Category	57A - Anatomy 57S - Physiology 99D - Basic & Synthetic Chemistry 57Y - Toxicology
Corporate Authors	ManTech Environmental Technology, Inc., Dayton, OH.
Document Type	Technical Report
Title Note	Final rept. Apr 93-Jan 94.
NTIS Issue Number	199606

Acute and Subacute Toxicity Evaluation of Ammonium Dinitramide.

Acute and Subacute Toxicity Evaluation of Ammonium Dinitramide.
ADA298965

Publication Date	1994
Personal Author	Kinkead, E. R.; Salins, S. A.; Wolfe, R. E.; Marit, G. B.
Page Count	17
Abstract	The Department of Defense is considering replacing ammonium perchiorate with ammonium dinitramide (ADN). Ammonium dinitramide, a Class 1.1 explosive oxidizer, would be used in solid rocket engine propellant mixtures as well as used as a high explosive. The first objective of this study was to provide acute hazard information on ADN to industrial hygienists responsible for the safe handling of this material. Because the most likely form of accidental exposure would be by the dermal or oral routes, acute oral and dermal toxicity tests were performed. Oral gavage of ADN solutions greater than 1 g/kg resulted in mortality preceded by convulsions. An oral LD50 of 823 mg/kg was determined for male Fischer 344 rats. Rats receiving nonlethal doses of ADN showed no treatment-related effects when necropsied following a 14-day observation period. Dermal toxicity in New Zealand white rabbits, performed at the Environmental Protection Agency's limit dose level of 2 g/kg body weight, resulted in no mortality, no clinical signs or differences in clinical pathology following a 14-day post-treatment observation period.
Keywords	Toxicity Skin(Anatomy) Ammonium perchlorate Test and evaluation Department of defense Hazards Exposure(General) Rats Test methods Clinical medicine Signs and symptoms Safety Specialists Handling High explosives Industrial hygiene Oral intake Rabbits White(Color) Accidents Convulsive disorders Dermatology New zealand Ammonium dinitramide Dermal toxicity Oral gavage
Source Agency	Non Paid ADAS
NTIS Subject Category	57A - Anatomy 57S - Physiology 99D - Basic & Synthetic Chemistry 57Y - Toxicology
Corporate Authors	ManTech Environmental Technology, Inc., Dayton, OH.
Document Type	Technical Report
Title Note	Final rept. Apr 93-Jan 94.
NTIS Issue Number	199606