National Technical Reports Library

The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

Details

Subchronic Toxicity Studies on 1,3,5-Trinitrobenzene, 1,3-Dinitrobenzene, and Tetryl in Rats. Subchronic Toxicity Evaluation of N-Methyl-N, 2,4,6-Tetranitroaniline (Tetryl) in Fischer 344 Rats.

ADA290659

Publication Date	1994
Personal Author	Reddy, T. V.
Page Count	157
Abstract	Subchronic toxic effects of N-Methyl-N, 2,4,6-Tetranitroaniline (tetryl) in male and female Fisher 344 rats were evaluated by feeding powdered certified laboratory chow supplemented with varied concentrations of tetryl (0, 200, 1000 and 3000 mg/kg diet) for ninety days. There were no clinical signs of toxicity or early deaths. Food intake was reduced in both sexes at all dose levels throughout the study and resulted in a significant decrease in terminal body weights in the 3000 and 1000 mg tetryl dose groups. The calculated average tetryl dosage was 14, 69 and 199 mg/kg/day for females and 13, 62 and 180 mg/kg/day for males. An increase in the relative liver and kidney weights in both sexes in the 3000 and 1000 mg tetryl dose groups and an increase in the relative spleen weight in the 3000 mg dose group were noted. Hematology and clinical chemistry analyses were done at 45 and go days exposure. Methemoglobin levels were increased in both sexes in the 3000 and 1000 tetryl dose groups at 45 and 90 days while hemoglobin was decreased in these same groups at 90 days The red blood cell count was decreased in the 3000 mg tetryl dose group of both sexes while the reticulocyte count was increased in this same group. Cholesterol levels were increased in all dose groups in both sexes at 90 days. Histopathological examinations suggested that susceptible organs for tetryl toxicity were spleen (pigment deposition and erythroid cell hyperplasia) and kidneys (tubular degeneration and cytoplasmic droplets). A no observed adverse effect level (NOAEL) of 13 mg/kg/day was established.
Keywords	Toxicity Tetryl Chemical contamination Rats Synthesis(Chemistry) Counting methods Clinical medicine Signs and symptoms Deoxyribonucleic acids Chemistry Deposition Ground water Soils Drops Weight Adverse conditions Dosage Cholesterol Concentration(Composition) Level(Quantity) Tubular structures Cytoplasm Males Liver Environmental protection Pigments Hemoglobin Erythrocytes Tnt Body weight Females Methemoglobin Spleen Organs(Anatomy) Food consumption Kidneys Biodeterioration Hematology Dnb(1-3-dinitrobenzen)
Source Agency	Non Paid ADAS
NTIS Subject Category	57Y - Toxicology 99D - Basic & Synthetic Chemistry
Corporate Authors	Environmental Monitoring Systems Lab., Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	199520
Contract Number	MIPR-92MM2525

Subchronic Toxicity Studies on 1,3,5-Trinitrobenzene, 1,3-Dinitrobenzene, and Tetryl in Rats. Subchronic Toxicity Evaluation of N-Methyl-N, 2,4,6-Tetranitroaniline (Tetryl) in Fischer 344 Rats.

Subchronic Toxicity Studies on 1,3,5-Trinitrobenzene, 1,3-Dinitrobenzene, and Tetryl in Rats. Subchronic Toxicity Evaluation of N-Methyl-N, 2,4,6-Tetranitroaniline (Tetryl) in Fischer 344 Rats.
ADA290659

Publication Date	1994
Personal Author	Reddy, T. V.
Page Count	157
Abstract	Subchronic toxic effects of N-Methyl-N, 2,4,6-Tetranitroaniline (tetryl) in male and female Fisher 344 rats were evaluated by feeding powdered certified laboratory chow supplemented with varied concentrations of tetryl (0, 200, 1000 and 3000 mg/kg diet) for ninety days. There were no clinical signs of toxicity or early deaths. Food intake was reduced in both sexes at all dose levels throughout the study and resulted in a significant decrease in terminal body weights in the 3000 and 1000 mg tetryl dose groups. The calculated average tetryl dosage was 14, 69 and 199 mg/kg/day for females and 13, 62 and 180 mg/kg/day for males. An increase in the relative liver and kidney weights in both sexes in the 3000 and 1000 mg tetryl dose groups and an increase in the relative spleen weight in the 3000 mg dose group were noted. Hematology and clinical chemistry analyses were done at 45 and go days exposure. Methemoglobin levels were increased in both sexes in the 3000 and 1000 tetryl dose groups at 45 and 90 days while hemoglobin was decreased in these same groups at 90 days The red blood cell count was decreased in the 3000 mg tetryl dose group of both sexes while the reticulocyte count was increased in this same group. Cholesterol levels were increased in all dose groups in both sexes at 90 days. Histopathological examinations suggested that susceptible organs for tetryl toxicity were spleen (pigment deposition and erythroid cell hyperplasia) and kidneys (tubular degeneration and cytoplasmic droplets). A no observed adverse effect level (NOAEL) of 13 mg/kg/day was established.
Keywords	Toxicity Tetryl Chemical contamination Rats Synthesis(Chemistry) Counting methods Clinical medicine Signs and symptoms Deoxyribonucleic acids Chemistry Deposition Ground water Soils Drops Weight Adverse conditions Dosage Cholesterol Concentration(Composition) Level(Quantity) Tubular structures Cytoplasm Males Liver Environmental protection Pigments Hemoglobin Erythrocytes Tnt Body weight Females Methemoglobin Spleen Organs(Anatomy) Food consumption Kidneys Biodeterioration Hematology Dnb(1-3-dinitrobenzen)
Source Agency	Non Paid ADAS
NTIS Subject Category	57Y - Toxicology 99D - Basic & Synthetic Chemistry
Corporate Authors	Environmental Monitoring Systems Lab., Cincinnati, OH.
Document Type	Technical Report
Title Note	Final rept.
NTIS Issue Number	199520
Contract Number	MIPR-92MM2525