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Progressive Pulmonary Pathology of Two Organofluorine Compounds in Rats. (Reannouncement with New Availability Information).

ADA235230

Publication Date	1991
Personal Author	Nold, J. B.; Petrali, J. P.; Wall, H. G.; Moore, D. H.
Page Count	16
Abstract	Rat lungs were studied by light and electron microscopy to morphologically characterize the development of lung injury associated with the inhalation of two organofluorine compounds, perfluoroisobutylene (PFIB) and bis(trifluiromethyl) disulfide (TFD). Rats were exposed to test compounds in an inhalation chamber and euthanatized at 5 min, 30 min, 90 min, 4 h, 12 h,24 h, and 72 h postexposure. Inhalation of the compounds resulted in a progressive pulmonary pathology dominated by pulmonary edema and fibrin deposition, which peaked at 12 to 24 h but which resolved to a large extent by 27 h postexposure. The edema was microscopically evident as early as 5-30 min after exposure. Endothelial change was the earliest recognized lesion by electron microscopy and was produced by both compounds. This was characterized by increased pinocytotic-vesicular activity and increased electron density of endothelial cells. Injury to type I and II pneumocytes was also evident, but appeared more severe in the lungs of TFD-exposed rats. The morphologic pathogenesis of the edema appears related to the primary endothelial changes and concomitant pneumocyte damage.
Keywords	Lung Pathology Cells(Biology) Chambers Deposition Electron density Electrons Endothelium Exposure(General) Fluorides Inhalation Morphology Organic compounds Pathogenesis Wounds and injuries Reprints Organofluorine compounds Toxicology Pulmonary edema Light and electron microscopy Respiratory agents Perfluoroiso butylene Fibrin deposition morphology BIS(Trifluoromethyl) Disulfide
Source Agency	Non Paid Reprints
NTIS Subject Category	57Y - Toxicology 57S - Physiology
Corporate Authors	Army Medical Research Inst. of Chemical Defense, Aberdeen Proving Ground, MD.
Document Type	Journal Article
NTIS Issue Number	199517

Progressive Pulmonary Pathology of Two Organofluorine Compounds in Rats. (Reannouncement with New Availability Information).

Progressive Pulmonary Pathology of Two Organofluorine Compounds in Rats. (Reannouncement with New Availability Information).
ADA235230

Publication Date	1991
Personal Author	Nold, J. B.; Petrali, J. P.; Wall, H. G.; Moore, D. H.
Page Count	16
Abstract	Rat lungs were studied by light and electron microscopy to morphologically characterize the development of lung injury associated with the inhalation of two organofluorine compounds, perfluoroisobutylene (PFIB) and bis(trifluiromethyl) disulfide (TFD). Rats were exposed to test compounds in an inhalation chamber and euthanatized at 5 min, 30 min, 90 min, 4 h, 12 h,24 h, and 72 h postexposure. Inhalation of the compounds resulted in a progressive pulmonary pathology dominated by pulmonary edema and fibrin deposition, which peaked at 12 to 24 h but which resolved to a large extent by 27 h postexposure. The edema was microscopically evident as early as 5-30 min after exposure. Endothelial change was the earliest recognized lesion by electron microscopy and was produced by both compounds. This was characterized by increased pinocytotic-vesicular activity and increased electron density of endothelial cells. Injury to type I and II pneumocytes was also evident, but appeared more severe in the lungs of TFD-exposed rats. The morphologic pathogenesis of the edema appears related to the primary endothelial changes and concomitant pneumocyte damage.
Keywords	Lung Pathology Cells(Biology) Chambers Deposition Electron density Electrons Endothelium Exposure(General) Fluorides Inhalation Morphology Organic compounds Pathogenesis Wounds and injuries Reprints Organofluorine compounds Toxicology Pulmonary edema Light and electron microscopy Respiratory agents Perfluoroiso butylene Fibrin deposition morphology BIS(Trifluoromethyl) Disulfide
Source Agency	Non Paid Reprints
NTIS Subject Category	57Y - Toxicology 57S - Physiology
Corporate Authors	Army Medical Research Inst. of Chemical Defense, Aberdeen Proving Ground, MD.
Document Type	Journal Article
NTIS Issue Number	199517