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Determination of the Acute and Subchronic Mammalian Toxicity of HMX.

ADA173743

Publication Date	1985
Personal Author	Wilson, A. B.
Page Count	32
Abstract	Octahydro-1,3,5,7-tetranitro-1,3,5,7 tetrazocine(HMX) (CAS-2691-41-0) is an explosive and is found in the water effluent from the manufacturing processes for RDX and HMX. As part of the biological safety evaluation of the material, a series of toxicity and related studies was carried out in laboratory animals. The work comprised acute toxicology(rodent and rabbit LD50, skin and eye irritation, dermal toxicity and guinea pig sensitisation), 13 week dietary feeding studies in rates and mice(together with 14 day dose range finding studies), analysis of diets, analysis of bolld levels in the 13 week rodent studies and toxicokinetic investigations in rates and mice. Results of the investigation are summarized.
Keywords	HMX Toxicity Mammals Toxicology Oral dosage Skin(Anatomy) Eye Irritation Lethal dosage Sensitivity Diet Blood analysis Rabbits Rates Mice Guinea pigs Body weight Food consumption Foreign technology LPM-IRI-415669 LPM-IRI-416877 Explosives CAS 2691-41-0
Source Agency	Non Paid ADAS
NTIS Subject Category	57Y - Toxicology 79A - Ammunition, Explosives, & Pyrotechnics
Corporate Authors	Inveresk Research International Ltd., Edinburgh (Scotland).
Document Type	Technical Report
Title Note	Final summary rept. Mar 80-Jan 83.
NTIS Issue Number	198704
Contract Number	DAMD17-80-C-0053

Determination of the Acute and Subchronic Mammalian Toxicity of HMX.

Determination of the Acute and Subchronic Mammalian Toxicity of HMX.
ADA173743

Publication Date	1985
Personal Author	Wilson, A. B.
Page Count	32
Abstract	Octahydro-1,3,5,7-tetranitro-1,3,5,7 tetrazocine(HMX) (CAS-2691-41-0) is an explosive and is found in the water effluent from the manufacturing processes for RDX and HMX. As part of the biological safety evaluation of the material, a series of toxicity and related studies was carried out in laboratory animals. The work comprised acute toxicology(rodent and rabbit LD50, skin and eye irritation, dermal toxicity and guinea pig sensitisation), 13 week dietary feeding studies in rates and mice(together with 14 day dose range finding studies), analysis of diets, analysis of bolld levels in the 13 week rodent studies and toxicokinetic investigations in rates and mice. Results of the investigation are summarized.
Keywords	HMX Toxicity Mammals Toxicology Oral dosage Skin(Anatomy) Eye Irritation Lethal dosage Sensitivity Diet Blood analysis Rabbits Rates Mice Guinea pigs Body weight Food consumption Foreign technology LPM-IRI-415669 LPM-IRI-416877 Explosives CAS 2691-41-0
Source Agency	Non Paid ADAS
NTIS Subject Category	57Y - Toxicology 79A - Ammunition, Explosives, & Pyrotechnics
Corporate Authors	Inveresk Research International Ltd., Edinburgh (Scotland).
Document Type	Technical Report
Title Note	Final summary rept. Mar 80-Jan 83.
NTIS Issue Number	198704
Contract Number	DAMD17-80-C-0053