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HMX: 13 Week Toxicity Study in Mice by Dietary Administration.

ADA171602

Publication Date	1985
Personal Author	Everett, D. J.; Maddock, S. M.
Page Count	328
Abstract	Mice were fed diets containing HMX for 13 weeks. Dose levels for males were 0, 5, 12, 30, 75 or 200 mg HMX/kg/day. Female mice received 0, 10, 30, 90, 250 or 750 mg HMX/kg/day. Mortalities attributable to HMX at 200 mg HMX/kg/day amongst males and at 250 and 750 mg HMX/kg/day amongst females. Occasional deaths at lower dose levels were of uncertain aetiology. No marked effects on body weight were noted although food consumption was reduced amongst higher dosed males and females. There were slight but equivocal changes in haematological and clinical chemical observations. Neither gross autopsy nor histopathology revealed any findings likely to be associated with the administration of HMX.
Keywords	Toxicology HMX Diet Explosives Dosage Mortality rates Toxicity Food consumption Reduction Hematology Bioassay Urine Histopathology Body weight Mice Foreign technology
Source Agency	Non Paid ADAS
NTIS Subject Category	57Y - Toxicology 79A - Ammunition, Explosives, & Pyrotechnics
Corporate Authors	Inveresk Research International Ltd., Edinburgh (Scotland).
Document Type	Technical Report
Title Note	Final rept. Jan-Nov 81.
NTIS Issue Number	198626
Contract Number	DAMD17-80-C-0053

HMX: 13 Week Toxicity Study in Mice by Dietary Administration.

HMX: 13 Week Toxicity Study in Mice by Dietary Administration.
ADA171602

Publication Date	1985
Personal Author	Everett, D. J.; Maddock, S. M.
Page Count	328
Abstract	Mice were fed diets containing HMX for 13 weeks. Dose levels for males were 0, 5, 12, 30, 75 or 200 mg HMX/kg/day. Female mice received 0, 10, 30, 90, 250 or 750 mg HMX/kg/day. Mortalities attributable to HMX at 200 mg HMX/kg/day amongst males and at 250 and 750 mg HMX/kg/day amongst females. Occasional deaths at lower dose levels were of uncertain aetiology. No marked effects on body weight were noted although food consumption was reduced amongst higher dosed males and females. There were slight but equivocal changes in haematological and clinical chemical observations. Neither gross autopsy nor histopathology revealed any findings likely to be associated with the administration of HMX.
Keywords	Toxicology HMX Diet Explosives Dosage Mortality rates Toxicity Food consumption Reduction Hematology Bioassay Urine Histopathology Body weight Mice Foreign technology
Source Agency	Non Paid ADAS
NTIS Subject Category	57Y - Toxicology 79A - Ammunition, Explosives, & Pyrotechnics
Corporate Authors	Inveresk Research International Ltd., Edinburgh (Scotland).
Document Type	Technical Report
Title Note	Final rept. Jan-Nov 81.
NTIS Issue Number	198626
Contract Number	DAMD17-80-C-0053