National Technical Reports Library

The National Technical Information Service acquires, indexes, abstracts, and archives the largest collection of U.S. government-sponsored technical reports in existence. The NTRL offers online, free and open access to these authenticated government technical reports. Technical reports and documents in its repository may be available online for free either from the issuing federal agency, the U.S. Government Publishing Office’s Federal Digital System website, or through search engines.

Details

ADA168236

Publication Date	1986
Personal Author	Morgan, E. W.; Hiatt, G. F.; Lewis, C. M.; Korte, D. W.
Page Count	93
Abstract	The acute oral toxicity of (E)-1,2,3,4-tetrahydro-6-methyl-1-(2-methyl-1-Oxo-2-Butenyl) Quinoline (CHR5) was determined in Sprague-Dawley rats by using the oral gavage single-dose method. The LD50 was 2.73 g/kg for male rats and 2.22 g/kg for female rats. CHR5 produces a syndrome of general malaise and appears to target the upper gastrointestinal tract and the central nervous system. The predominate GI sign was increased salivation. CNS signs included loss of equilibrium, twitching, tremors, hypotonia, and depression of the grasping, pinch, pull, and righting reflexes. Keywords: Insect repellent, and Toxicology.
Keywords	Toxicity Insect repellents Oral intake Quinolines Oral dosage Central nervous system Equilibrium(General) Females Gastrointestinal system Losses Malaise Males Rates Rats Signs and symptoms Toxicology Tremors Lethal dosage Saliva Quinaline/(methyl-oxobutenyl)-methyl-tetrahydro)
Source Agency	Non Paid ADAS
NTIS Subject Category	57Y - Toxicology 57Z - Zoology 57H - Ecology
Corporate Authors	Letterman Army Inst. of Research, Presidio of San Francisco, CA.
Document Type	Technical Report
Title Note	Final rept. 18 Nov-16 Dec 83, 25 Apr-16 May 84.
NTIS Issue Number	198619

Acute Oral Toxicity of (E)-1,2,3,4-Tetrahydro-6-Methyl-1-(2-Methyl-1-Oxo-2-Butenyl) Quinoline (CHR5) in Male and Female Rats.

Acute Oral Toxicity of (E)-1,2,3,4-Tetrahydro-6-Methyl-1-(2-Methyl-1-Oxo-2-Butenyl) Quinoline (CHR5) in Male and Female Rats.
ADA168236

Publication Date	1986
Personal Author	Morgan, E. W.; Hiatt, G. F.; Lewis, C. M.; Korte, D. W.
Page Count	93
Abstract	The acute oral toxicity of (E)-1,2,3,4-tetrahydro-6-methyl-1-(2-methyl-1-Oxo-2-Butenyl) Quinoline (CHR5) was determined in Sprague-Dawley rats by using the oral gavage single-dose method. The LD50 was 2.73 g/kg for male rats and 2.22 g/kg for female rats. CHR5 produces a syndrome of general malaise and appears to target the upper gastrointestinal tract and the central nervous system. The predominate GI sign was increased salivation. CNS signs included loss of equilibrium, twitching, tremors, hypotonia, and depression of the grasping, pinch, pull, and righting reflexes. Keywords: Insect repellent, and Toxicology.
Keywords	Toxicity Insect repellents Oral intake Quinolines Oral dosage Central nervous system Equilibrium(General) Females Gastrointestinal system Losses Malaise Males Rates Rats Signs and symptoms Toxicology Tremors Lethal dosage Saliva Quinaline/(methyl-oxobutenyl)-methyl-tetrahydro)
Source Agency	Non Paid ADAS
NTIS Subject Category	57Y - Toxicology 57Z - Zoology 57H - Ecology
Corporate Authors	Letterman Army Inst. of Research, Presidio of San Francisco, CA.
Document Type	Technical Report
Title Note	Final rept. 18 Nov-16 Dec 83, 25 Apr-16 May 84.
NTIS Issue Number	198619