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Determination of the Chronic Mammalian Toxicological Effects of TNT. Twenty-Six Week Subchronic Oral Toxicity Study of Trinitrotoluene (TNT) in the Beagle Dog.

ADA157082

Publication Date	1983
Personal Author	Levine, B. S.; Rust, J.; Burns, J. M.; Lish, P. M.
Page Count	312
Abstract	This study was conducted to evaluate the toxicity of the munitions compound 2,4,6-trinitrotoluene (TNT; CAS Reg. No. 118-96-7) in beagle dogs when administered daily for 26 weeks by capsule. Groups of six dogs per sex received TNT at doses of 0 (vehicle controls), 0.5, 2, 8, or 32 mg/kg/day. Toxicologic endpoints included clinical signs, body weights, food consumption, clinical chemistry, hematology, urinalyses, organ weights, and gross and tissue morphology. The major toxic effects following the oral administration of TNT to dogs included hemolytic anemia, hepatomegaly and splenomegaly with accompanying histologic lesions, and death. Only the highest dose given (32 mg/kg/day) proved to be lethal. Hepatic cloudy swelling and hepatocytomegalia were apparent at all doses tested, thus a no observable effect level was not established in the present study. (Author)
Keywords	Toxicology Tnt Toxicity Dosage Body weight Clinical medicine Signs and symptoms Dogs Food consumption Hematology Mammals Death Morphology(Biology) Tissues(Biology) Anemias Lesions Physiological effects Organs(Anatomy) Weight Splenomegaly Chemical analysis Urine
Source Agency	Non Paid ADAS
NTIS Subject Category	57Y - Toxicology 79A - Ammunition, Explosives, & Pyrotechnics 57D - Clinical Chemistry 99A - Analytical Chemistry 68 - Environmental Pollution & Control
Corporate Authors	IIT Research Inst., Chicago, IL.
Document Type	Technical Report
Title Note	Final study rept. no. 5, May-Nov 80 on Phase 2.
NTIS Issue Number	198523
Contract Number	DAMD17-79-C-9120

Determination of the Chronic Mammalian Toxicological Effects of TNT. Twenty-Six Week Subchronic Oral Toxicity Study of Trinitrotoluene (TNT) in the Beagle Dog.

Determination of the Chronic Mammalian Toxicological Effects of TNT. Twenty-Six Week Subchronic Oral Toxicity Study of Trinitrotoluene (TNT) in the Beagle Dog.
ADA157082

Publication Date	1983
Personal Author	Levine, B. S.; Rust, J.; Burns, J. M.; Lish, P. M.
Page Count	312
Abstract	This study was conducted to evaluate the toxicity of the munitions compound 2,4,6-trinitrotoluene (TNT; CAS Reg. No. 118-96-7) in beagle dogs when administered daily for 26 weeks by capsule. Groups of six dogs per sex received TNT at doses of 0 (vehicle controls), 0.5, 2, 8, or 32 mg/kg/day. Toxicologic endpoints included clinical signs, body weights, food consumption, clinical chemistry, hematology, urinalyses, organ weights, and gross and tissue morphology. The major toxic effects following the oral administration of TNT to dogs included hemolytic anemia, hepatomegaly and splenomegaly with accompanying histologic lesions, and death. Only the highest dose given (32 mg/kg/day) proved to be lethal. Hepatic cloudy swelling and hepatocytomegalia were apparent at all doses tested, thus a no observable effect level was not established in the present study. (Author)
Keywords	Toxicology Tnt Toxicity Dosage Body weight Clinical medicine Signs and symptoms Dogs Food consumption Hematology Mammals Death Morphology(Biology) Tissues(Biology) Anemias Lesions Physiological effects Organs(Anatomy) Weight Splenomegaly Chemical analysis Urine
Source Agency	Non Paid ADAS
NTIS Subject Category	57Y - Toxicology 79A - Ammunition, Explosives, & Pyrotechnics 57D - Clinical Chemistry 99A - Analytical Chemistry 68 - Environmental Pollution & Control
Corporate Authors	IIT Research Inst., Chicago, IL.
Document Type	Technical Report
Title Note	Final study rept. no. 5, May-Nov 80 on Phase 2.
NTIS Issue Number	198523
Contract Number	DAMD17-79-C-9120