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Chronic Inhalation Toxicity of Unsymmetrical Dimethylhydrazine: Oncogenic Effects.

ADA152208

Publication Date	1984
Personal Author	Haun, C. C.; Kinkead, E. R.; Vernot, E. H.; Gaworski, C. L.; MacEwen, J. D.
Page Count	53
Abstract	Four animal species were exposed for 6-months to selected vapor concentrations of propellant grade unsymmetrical dimethylhydrazine to determine its oncogenic effects. The UDMH concentrations at or near the current threshold limit value were 0.05, 0.5, and 5 ppm. Animals were maintained for various time periods postexposure as long as: hamsters, 17 months; mice and rats, 19 months; and dogs, 54 months. The lung was a target organ in rats while the liver was the main target of 5 ppm UDMH induced neoplastic changes in rats and mice. Rats had an increased incidence of bronchiolar adenomas compared to controls. Mice exposed to 5 ppm UDMH developed a 4.7% incidence of liver hemangiosarcomas while controls had a 0.7% incidence. Kupffer cell sarcomas were also increased in UDHM exposed mice.
Keywords	Inhalation Toxicity Dimethylhydrazines Carcinogens Dogs Lung Mice Hamsters Liver Neoplasms Rats Concentration(Chemistry) Exposure(General)
Source Agency	Air Force Non Paid ADAS
NTIS Subject Category	57Y - Toxicology 99A - Analytical Chemistry
Corporate Authors	California Univ., Dayton, OH.; Air Force Aerospace Medical Research Lab., Wright-Patterson AFB, OH.
Document Type	Technical Report
Title Note	Technical rept. Sep 74-Jun 80.
NTIS Issue Number	198513
Contract Number	F33615-80-C-0512

Chronic Inhalation Toxicity of Unsymmetrical Dimethylhydrazine: Oncogenic Effects.

Chronic Inhalation Toxicity of Unsymmetrical Dimethylhydrazine: Oncogenic Effects.
ADA152208

Publication Date	1984
Personal Author	Haun, C. C.; Kinkead, E. R.; Vernot, E. H.; Gaworski, C. L.; MacEwen, J. D.
Page Count	53
Abstract	Four animal species were exposed for 6-months to selected vapor concentrations of propellant grade unsymmetrical dimethylhydrazine to determine its oncogenic effects. The UDMH concentrations at or near the current threshold limit value were 0.05, 0.5, and 5 ppm. Animals were maintained for various time periods postexposure as long as: hamsters, 17 months; mice and rats, 19 months; and dogs, 54 months. The lung was a target organ in rats while the liver was the main target of 5 ppm UDMH induced neoplastic changes in rats and mice. Rats had an increased incidence of bronchiolar adenomas compared to controls. Mice exposed to 5 ppm UDMH developed a 4.7% incidence of liver hemangiosarcomas while controls had a 0.7% incidence. Kupffer cell sarcomas were also increased in UDHM exposed mice.
Keywords	Inhalation Toxicity Dimethylhydrazines Carcinogens Dogs Lung Mice Hamsters Liver Neoplasms Rats Concentration(Chemistry) Exposure(General)
Source Agency	Air Force Non Paid ADAS
NTIS Subject Category	57Y - Toxicology 99A - Analytical Chemistry
Corporate Authors	California Univ., Dayton, OH.; Air Force Aerospace Medical Research Lab., Wright-Patterson AFB, OH.
Document Type	Technical Report
Title Note	Technical rept. Sep 74-Jun 80.
NTIS Issue Number	198513
Contract Number	F33615-80-C-0512