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Acute Oral Toxicity of DMSO (Dimethyl Sulfoxide) Process Stream Samples in Male and Female Mice.

ADA137228

Publication Date	1983
Personal Author	White, C. W.; Rodriguez, J.; Marrs, G. E.
Page Count	54
Abstract	The acute toxicity of a single oral dose of the dimethyl sulfoxide stream samples DMSO Evaporator Sludge, DMSO Recycle Solvent, and Virgin DMSO was determined in male and female albino ICR mice. The DMSO Evaporator Sludge solution produced no deaths in male of female mice at a limit dose level of 5.0 ml/kg. The Virgin DMSO solution produced mortalities in one of seven males (14%) and two of seven females (29%) at a limit dose of 5.0 ml/kg. The DMSO Recycle Solvent LD (50) with 95 percent confidence limit was calculated by probit analysis. The DMSO REcycle Solvent LD50 was 4.0 ml/kg in male mice, 95 percent confidence limit (3.2 ml/kg, 5.1 ml/kg) and 2.5 ml/kg in female mice, 95 percent confidence limit (2.2 ml/kg, 2.8 ml/kg).
Keywords	Toxicity Methyl sulfoxide Dosage Oral intake Level(Quantity) Lethal dosage Mice Sampling Dimethyl sulfoxide DMOS(Dimethyl Sulfoxide)
Source Agency	Non Paid ADAS
NTIS Subject Category	57Y - Toxicology 57O - Pathology
Corporate Authors	Letterman Army Inst. of Research, Presidio of San Francisco, CA.
Document Type	Technical Report
Title Note	Final rept. 22 Dec 82-18 Jan 83 and 23 Mar-12 Apr 83.
NTIS Issue Number	198409

Acute Oral Toxicity of DMSO (Dimethyl Sulfoxide) Process Stream Samples in Male and Female Mice.

Acute Oral Toxicity of DMSO (Dimethyl Sulfoxide) Process Stream Samples in Male and Female Mice.
ADA137228

Publication Date	1983
Personal Author	White, C. W.; Rodriguez, J.; Marrs, G. E.
Page Count	54
Abstract	The acute toxicity of a single oral dose of the dimethyl sulfoxide stream samples DMSO Evaporator Sludge, DMSO Recycle Solvent, and Virgin DMSO was determined in male and female albino ICR mice. The DMSO Evaporator Sludge solution produced no deaths in male of female mice at a limit dose level of 5.0 ml/kg. The Virgin DMSO solution produced mortalities in one of seven males (14%) and two of seven females (29%) at a limit dose of 5.0 ml/kg. The DMSO Recycle Solvent LD (50) with 95 percent confidence limit was calculated by probit analysis. The DMSO REcycle Solvent LD50 was 4.0 ml/kg in male mice, 95 percent confidence limit (3.2 ml/kg, 5.1 ml/kg) and 2.5 ml/kg in female mice, 95 percent confidence limit (2.2 ml/kg, 2.8 ml/kg).
Keywords	Toxicity Methyl sulfoxide Dosage Oral intake Level(Quantity) Lethal dosage Mice Sampling Dimethyl sulfoxide DMOS(Dimethyl Sulfoxide)
Source Agency	Non Paid ADAS
NTIS Subject Category	57Y - Toxicology 57O - Pathology
Corporate Authors	Letterman Army Inst. of Research, Presidio of San Francisco, CA.
Document Type	Technical Report
Title Note	Final rept. 22 Dec 82-18 Jan 83 and 23 Mar-12 Apr 83.
NTIS Issue Number	198409