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Acute Oral Lethal Dose (LD50) in Male and Female Rats for CHR 8.

ADA121891

Publication Date	1982
Personal Author	Hanes, M. A.; Marrs, G. E.; Fruin, J. T.
Page Count	34
Abstract	The acute oral toxicity potential of CHR 8, a candidate insect repellent was tested in 40 young adult Sprague-Dawley Rats. Doses ranging from 1620 ul/kg to 5250 ul/kg body weight were tested based on an approximate lethal study. Probit analysis was used to derive values for the median lethal dose (LD50). Animals were single dosed and observed for 14 days. The LD50 for males was 4809.9 ul/kg with a 95% confidence range of 4035 - 5733 ul/kg. The LD50 for female rats for CHR 8 was 3136.5 ul/kg with a 95% confidence interval of 2654 - 3706 ul/kg. Corn oil was the vehicle control and diluent. The toxicity of this chemical is in the moderate to slightly toxic range. Continuation of planned human use experimentation is warranted. (Author)
Keywords	Toxicity Insect repellents Oral dosage Lethal dosage Tables(Data) Classification Death Rats Mortality rates Time
Source Agency	Non Paid ADAS
NTIS Subject Category	57Y - Toxicology 57O - Pathology
Corporate Authors	Letterman Army Inst. of Research, Presidio of San Francisco, CA.
Document Type	Technical Report
Title Note	Final rept. 30 Jun-9 Sep 81.
NTIS Issue Number	198306

Acute Oral Lethal Dose (LD50) in Male and Female Rats for CHR 8.

Acute Oral Lethal Dose (LD50) in Male and Female Rats for CHR 8.
ADA121891

Publication Date	1982
Personal Author	Hanes, M. A.; Marrs, G. E.; Fruin, J. T.
Page Count	34
Abstract	The acute oral toxicity potential of CHR 8, a candidate insect repellent was tested in 40 young adult Sprague-Dawley Rats. Doses ranging from 1620 ul/kg to 5250 ul/kg body weight were tested based on an approximate lethal study. Probit analysis was used to derive values for the median lethal dose (LD50). Animals were single dosed and observed for 14 days. The LD50 for males was 4809.9 ul/kg with a 95% confidence range of 4035 - 5733 ul/kg. The LD50 for female rats for CHR 8 was 3136.5 ul/kg with a 95% confidence interval of 2654 - 3706 ul/kg. Corn oil was the vehicle control and diluent. The toxicity of this chemical is in the moderate to slightly toxic range. Continuation of planned human use experimentation is warranted. (Author)
Keywords	Toxicity Insect repellents Oral dosage Lethal dosage Tables(Data) Classification Death Rats Mortality rates Time
Source Agency	Non Paid ADAS
NTIS Subject Category	57Y - Toxicology 57O - Pathology
Corporate Authors	Letterman Army Inst. of Research, Presidio of San Francisco, CA.
Document Type	Technical Report
Title Note	Final rept. 30 Jun-9 Sep 81.
NTIS Issue Number	198306