| Abstract |
This contract was awarded to provide for the conduct of toxicological evaluations on various drugs under study by WRAIR. In general, these acute and subacute studies were designed to evaluate and characterize the pharmacotoxic signs of these drugs to support the IND. Eighteen studies were performed over the period of this contract. WR-2823 (AU 69115) was evaluated for acute oral toxicity by oral intubation to three groups of two male rats each at dosage levels of 100, 1000, and 10,000 mg/kg of body weight (acute oral dose range) in order to more accurately define the toxic range prior to initiating an expanded LD50 study. WR-2823 (AU 69115) was then further evaluated for acute oral toxicity by oral intubation to eight groups of 10 male rats each at dosage levels of 100 to 2150 mg/kg of body weight. The acute oral LD50 was found to be 2037 mg/kg of body weight (confidence limits, 1281 to 3239 mg/kg of body weight). Signs of toxic effect included depression, labored respiration, hunched appearance, diarrhea or brown stains on body, squinting, ptosis, lacrimation, reddened eyes, yellow stain on fur, urine stain, and slight ataxia. |
