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Mammalian Toxicity of Munitions Compounds. Phase I. Acute Oral Toxicity, Primary Skin and Eye Irritation, Dermal Sensitization, Disposition and Metabolism and Ames Tests of Additional Compounds.

ADA069333

Publication Date	1978
Personal Author	Ellis, H. V.; Hodgson, J. R.; Hwang, S. W.; Halpap, L. M.; Helton, D. O.
Page Count	48
Abstract	Tests indicated that 3,5-Dinitrotoluene (3,5-DNT) was the most potent of all DNT isomers in oral acute doses to rats and mice. 2-Amino-4, 6-DNT (2-ADNT) and its isomer, 4-ADNT, were the least potent in rats and female mice, and comparable to 2,3-DNT and 2,4-DNT in male mice. 3.5-DNT and 4-ADNT were not irritating to rabbit skin; 2-ADNT was a mild irritant. All three compounds were not irritating to rabbit eyes and not sensitizing to guinea pigs. 3,5-DNT and 4-ADNT were absorbed from the gastrointestinal tract, metabolized and excreted in the urine. In the Ames test, 1,3-dinitroglycerin (1,3-DNG), 1-mononitroglycerin (1-MNG), nitrocellulose and white phosphorus were not mutagenic. Trinitrotoluene (TNT) 2,4-DNT, 2,5-DNT, tetranitromethane (TNM) and 1,2-DNG were mutagenic at 10 to 30 microgram/plate in one or more strains. TNM was bactericidal without activation. 1,2-DNG was nonmutagenic with activation. 2,3-DNT, 2,6-DNT, 3,5-DNT, trinitroglycerin and 2-MNG were weakly mutagenic, with mutagenic results at 100 or 1,000 microgram/plate in one or more strains.
Keywords	Nitrotoluenes Ammunition Toxicity TNT Mammals Skin(Anatomy) Eye Sensitivity Metabolism Rabbits Guinea pigs Mice Rats Amines Radioactivity Excretion Tables(Data) Toxicology Toxic substances Dinitrotoluenes Toluene/dinitro Toluene/amino-dinitro Glycerin/dinitro Glycerin/nitro Celulose/nitro Methane/tetranitro
Source Agency	Non Paid ADAS
NTIS Subject Category	57Y - Toxicology 79A - Ammunition, Explosives, & Pyrotechnics
Corporate Authors	Midwest Research Inst Kansas City MO
Document Type	Technical Report
Title Note	Progress rept. no. 6 1 Feb 75-28 Feb 78.
NTIS Issue Number	197921
Contract Number	DAMD17-74-C-4073

Mammalian Toxicity of Munitions Compounds. Phase I. Acute Oral Toxicity, Primary Skin and Eye Irritation, Dermal Sensitization, Disposition and Metabolism and Ames Tests of Additional Compounds.

Mammalian Toxicity of Munitions Compounds. Phase I. Acute Oral Toxicity, Primary Skin and Eye Irritation, Dermal Sensitization, Disposition and Metabolism and Ames Tests of Additional Compounds.
ADA069333

Publication Date	1978
Personal Author	Ellis, H. V.; Hodgson, J. R.; Hwang, S. W.; Halpap, L. M.; Helton, D. O.
Page Count	48
Abstract	Tests indicated that 3,5-Dinitrotoluene (3,5-DNT) was the most potent of all DNT isomers in oral acute doses to rats and mice. 2-Amino-4, 6-DNT (2-ADNT) and its isomer, 4-ADNT, were the least potent in rats and female mice, and comparable to 2,3-DNT and 2,4-DNT in male mice. 3.5-DNT and 4-ADNT were not irritating to rabbit skin; 2-ADNT was a mild irritant. All three compounds were not irritating to rabbit eyes and not sensitizing to guinea pigs. 3,5-DNT and 4-ADNT were absorbed from the gastrointestinal tract, metabolized and excreted in the urine. In the Ames test, 1,3-dinitroglycerin (1,3-DNG), 1-mononitroglycerin (1-MNG), nitrocellulose and white phosphorus were not mutagenic. Trinitrotoluene (TNT) 2,4-DNT, 2,5-DNT, tetranitromethane (TNM) and 1,2-DNG were mutagenic at 10 to 30 microgram/plate in one or more strains. TNM was bactericidal without activation. 1,2-DNG was nonmutagenic with activation. 2,3-DNT, 2,6-DNT, 3,5-DNT, trinitroglycerin and 2-MNG were weakly mutagenic, with mutagenic results at 100 or 1,000 microgram/plate in one or more strains.
Keywords	Nitrotoluenes Ammunition Toxicity TNT Mammals Skin(Anatomy) Eye Sensitivity Metabolism Rabbits Guinea pigs Mice Rats Amines Radioactivity Excretion Tables(Data) Toxicology Toxic substances Dinitrotoluenes Toluene/dinitro Toluene/amino-dinitro Glycerin/dinitro Glycerin/nitro Celulose/nitro Methane/tetranitro
Source Agency	Non Paid ADAS
NTIS Subject Category	57Y - Toxicology 79A - Ammunition, Explosives, & Pyrotechnics
Corporate Authors	Midwest Research Inst Kansas City MO
Document Type	Technical Report
Title Note	Progress rept. no. 6 1 Feb 75-28 Feb 78.
NTIS Issue Number	197921
Contract Number	DAMD17-74-C-4073