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Changes in Left Ventricular Internal Diameter with Increasing Pericardial Pressure.

ADA050519

Publication Date	1975
Personal Author	Pegram, B. L.; Kardon, M. B.; Bishop, V. S.
Page Count	12
Abstract	Changes in left ventricular internal diameter resulting from increasing intrapericardial pressure induced by increasing the pericardial fluid volume were studied in closed chest, anaesthetized dogs. Left ventricular internal diameters were measured by placing an ultrasonic dimension catheter in the left ventricle at the time of the experiments. With increasing pericardial pressure, significant increases occurred in heart rate and mean left atrial pressure. Left ventricular end-diastolic and end-systolic diameter progressively decreased as the pericardial pressure was elevated. After beta adrenergic blockade with propranolol (1 mg/kg), the decline in end-systolic diameter during pericardial tamponade was significantly reduced. These observations indicate the importance of the systolic reserve and the role of beta adrenergic receptors in the adaptation of the left ventricle to increases in pericardial tamponade. (Author)
Keywords	Ventricles Heart Sympathetic nervous system Pericardium Pressure Diameters Internal Compression Compensation Heart rate Blood pressure Catecholamines Cardiovascular agents Blocking Cardiology Dogs Reprints Cardiac tamponade Adrenergic receptors Propanolol
Source Agency	Non Paid Reprints
NTIS Subject Category	57S - Physiology
Corporate Authors	Texas Univ Health Science Center At San Antonio Dept of Pharmacology
Document Type	Journal Article
Title Note	Interim rept.
NTIS Issue Number	197811

Changes in Left Ventricular Internal Diameter with Increasing Pericardial Pressure.

Changes in Left Ventricular Internal Diameter with Increasing Pericardial Pressure.
ADA050519

Publication Date	1975
Personal Author	Pegram, B. L.; Kardon, M. B.; Bishop, V. S.
Page Count	12
Abstract	Changes in left ventricular internal diameter resulting from increasing intrapericardial pressure induced by increasing the pericardial fluid volume were studied in closed chest, anaesthetized dogs. Left ventricular internal diameters were measured by placing an ultrasonic dimension catheter in the left ventricle at the time of the experiments. With increasing pericardial pressure, significant increases occurred in heart rate and mean left atrial pressure. Left ventricular end-diastolic and end-systolic diameter progressively decreased as the pericardial pressure was elevated. After beta adrenergic blockade with propranolol (1 mg/kg), the decline in end-systolic diameter during pericardial tamponade was significantly reduced. These observations indicate the importance of the systolic reserve and the role of beta adrenergic receptors in the adaptation of the left ventricle to increases in pericardial tamponade. (Author)
Keywords	Ventricles Heart Sympathetic nervous system Pericardium Pressure Diameters Internal Compression Compensation Heart rate Blood pressure Catecholamines Cardiovascular agents Blocking Cardiology Dogs Reprints Cardiac tamponade Adrenergic receptors Propanolol
Source Agency	Non Paid Reprints
NTIS Subject Category	57S - Physiology
Corporate Authors	Texas Univ Health Science Center At San Antonio Dept of Pharmacology
Document Type	Journal Article
Title Note	Interim rept.
NTIS Issue Number	197811