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Maturation of Murine B Lymphocytes.

ADA044375

Publication Date	1977
Personal Author	Scher, I.; Ahmed, A.; Sharrow, S. O.; Paul, W. E.
Page Count	22
Abstract	Precursor B lymphocytes have been identified in fetal mouse livers by their ability to produce Ig-positive lymphocytes. Specific surface markers identifying these precursor cells have not been identified. Primitive Ig-positive lymphocytes bear detectable Ig and are found in fetal livers at 17 days gestation (stage 1). Among the Ig-positive cells in neonatal spleens is a population that bear a relatively high density of surface IgM and fails to express the Mls-determined LADs, surface IgD, or the complement receptor (stage 2). Development of the peak of splenic B lymphocytes with a low-to-intermediate density of surface Ig occurs at approximately the same time as development of surface IgD (stages 3 and 4). During this same period, the number of splenic B lymphocytes with a relatively high density of surface IgM decreases. These data suggest that B lymphocytes that express IgD do so as the quantity of IgM on their surface decreases to a relatively low density (stages 2 to 4). Acquisition of IgD by B lymphocytes with a low density of surface IgM could explain the development of the population of cells with a low-to-intermediate density of total surface Ig that appears in the spleens of maturing mice. Lymphocytes that bear the complement receptor or that express the Mls-determined LADs are found in the spleens of mice that are 2 to 3 weeks old, but their levels do not reach those of adult mice until after 4 weeks.
Keywords	Lymphocytes Immunoglobulins Maturation Precursors Ontogeny Liver Mice Strains(Biology) Fetus Adults Spleen Growth(Physiology) Antigens Surface properties Reprints B Lymphocytes Neonates
Source Agency	Non Paid Reprints
NTIS Subject Category	57J - Immunology
Corporate Authors	Naval Medical Research Inst Bethesda MD
Document Type	Journal Article
Title Note	Medical research progress rept.
NTIS Issue Number	197724

Maturation of Murine B Lymphocytes.

Maturation of Murine B Lymphocytes.
ADA044375

Publication Date	1977
Personal Author	Scher, I.; Ahmed, A.; Sharrow, S. O.; Paul, W. E.
Page Count	22
Abstract	Precursor B lymphocytes have been identified in fetal mouse livers by their ability to produce Ig-positive lymphocytes. Specific surface markers identifying these precursor cells have not been identified. Primitive Ig-positive lymphocytes bear detectable Ig and are found in fetal livers at 17 days gestation (stage 1). Among the Ig-positive cells in neonatal spleens is a population that bear a relatively high density of surface IgM and fails to express the Mls-determined LADs, surface IgD, or the complement receptor (stage 2). Development of the peak of splenic B lymphocytes with a low-to-intermediate density of surface Ig occurs at approximately the same time as development of surface IgD (stages 3 and 4). During this same period, the number of splenic B lymphocytes with a relatively high density of surface IgM decreases. These data suggest that B lymphocytes that express IgD do so as the quantity of IgM on their surface decreases to a relatively low density (stages 2 to 4). Acquisition of IgD by B lymphocytes with a low density of surface IgM could explain the development of the population of cells with a low-to-intermediate density of total surface Ig that appears in the spleens of maturing mice. Lymphocytes that bear the complement receptor or that express the Mls-determined LADs are found in the spleens of mice that are 2 to 3 weeks old, but their levels do not reach those of adult mice until after 4 weeks.
Keywords	Lymphocytes Immunoglobulins Maturation Precursors Ontogeny Liver Mice Strains(Biology) Fetus Adults Spleen Growth(Physiology) Antigens Surface properties Reprints B Lymphocytes Neonates
Source Agency	Non Paid Reprints
NTIS Subject Category	57J - Immunology
Corporate Authors	Naval Medical Research Inst Bethesda MD
Document Type	Journal Article
Title Note	Medical research progress rept.
NTIS Issue Number	197724