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Experimental Investigation of the Toxicity of Certain Fluoroaromatic Compounds (Eksperimentalnoe Izuchenie Toksichnosti Nekotorykh Ftoraromaticheskikh Soedinenii).

AD670902

Publication Date	1967
Personal Author	Lapik, A. S.
Page Count	9
Abstract	The article gives the results of primary investigation of the severe toxicity of certain fluorinated aromatic compounds -- monofluorbenzene, ortho-, meta-, and para-difluorbenzenes hexafluorbenzene, pentafluoraniline, and pentafluorphenol -- synthesized at the Novosibirsk Institute of Organic Chemistry, Siberian Department, Academy of Sciences USSR. Mice 5-6 months old were intoxicated with fumes of the fluorine compounds in a special chamber. Exposure time was two hours. The mice were observed for 24 hours. The author concludes that fluorination of benzene intensifies the narcotic properties of the compound without essentially changing its toxicity. Fluorination of aniline and phenol intensifies the toxicity of the compounds with a notable change in the clinical aspects of poisoning, in that the neurotoxic effect is intensified. (Author)
Keywords	Fluorination Aromatic compounds Toxicity Benzenes Phenols Mice Exposure Poisoning Central nervous system Skin USSR Anilines Translations
NTIS Subject Category	99D - Basic & Synthetic Chemistry 57Y - Toxicology
Corporate Authors	Foreign Technology Div Wright-Patterson AFB Ohio
Supplemental Notes	Unedited rough draft trans. of Akademiya Nauk SSSR. Sibirskoe Otdelenie. Izvestiya, n4, Seriya Biologo-Meditsinskikh Nauk, n3 p91-4 1965.
Document Type	Technical Report
NTIS Issue Number	196816

Experimental Investigation of the Toxicity of Certain Fluoroaromatic Compounds (Eksperimentalnoe Izuchenie Toksichnosti Nekotorykh Ftoraromaticheskikh Soedinenii).

Experimental Investigation of the Toxicity of Certain Fluoroaromatic Compounds (Eksperimentalnoe Izuchenie Toksichnosti Nekotorykh Ftoraromaticheskikh Soedinenii).
AD670902

Publication Date	1967
Personal Author	Lapik, A. S.
Page Count	9
Abstract	The article gives the results of primary investigation of the severe toxicity of certain fluorinated aromatic compounds -- monofluorbenzene, ortho-, meta-, and para-difluorbenzenes hexafluorbenzene, pentafluoraniline, and pentafluorphenol -- synthesized at the Novosibirsk Institute of Organic Chemistry, Siberian Department, Academy of Sciences USSR. Mice 5-6 months old were intoxicated with fumes of the fluorine compounds in a special chamber. Exposure time was two hours. The mice were observed for 24 hours. The author concludes that fluorination of benzene intensifies the narcotic properties of the compound without essentially changing its toxicity. Fluorination of aniline and phenol intensifies the toxicity of the compounds with a notable change in the clinical aspects of poisoning, in that the neurotoxic effect is intensified. (Author)
Keywords	Fluorination Aromatic compounds Toxicity Benzenes Phenols Mice Exposure Poisoning Central nervous system Skin USSR Anilines Translations
NTIS Subject Category	99D - Basic & Synthetic Chemistry 57Y - Toxicology
Corporate Authors	Foreign Technology Div Wright-Patterson AFB Ohio
Supplemental Notes	Unedited rough draft trans. of Akademiya Nauk SSSR. Sibirskoe Otdelenie. Izvestiya, n4, Seriya Biologo-Meditsinskikh Nauk, n3 p91-4 1965.
Document Type	Technical Report
NTIS Issue Number	196816